Which of the following statements best express the relationship between the nervous system and the endocrine system?

The nervous system and endocrine system both use chemical messengers to signal cells, but each has a different transmission speed.

Learning Objectives

  • Distinguish between the nervous system and the endocrine system

Key Points

  • The nervous system can respond quickly to stimuli, through the use of action potentials and neurotransmitters.
  • Responses to nervous system stimulation are typically quick but short lived.
  • The endocrine system responds to stimulation by secreting hormones into the circulatory system that travel to the target tissue.
  • Responses to endocrine system stimulation are typically slow but long lasting.

  • hormone: A molecule released by a cell or a gland in one part of the body that sends out messages affecting cells in other parts of the organism.
  • neurotransmitters: Endogenous chemicals that transmit signals from a neuron to a target cell across a synapse.

The body must maintain a constant internal environment, through a process termed homeostasis, while also being able to respond and adapt to external events. The nervous and endocrine systems both work to bring about this adaptation, but their response patterns are different. The nervous system and the endocrine system use chemical messengers to signal cells, but the speed at which these messages are transmitted and the length of their effects differs.

The nervous system responds rapidly to stimuli by sending electrical action potentials along neurons, which in turn transmit these action potentials to their target cells using neurotransmitters, the chemical messenger of the nervous system. The response to stimuli by the nervous system is near instantaneous, although the effects are often short lived. An example is the recoil mechanism of an arm when touching something hot.

The endocrine system relies on hormones to elicit responses from target cells. These hormones are synthesized in specialized glands at a distance from their target, and travel through the bloodstream or inter-cellular fluid. Upon reaching their target, hormones can induce cellular responses at a protein or genetic level.

This process takes significantly longer than that of the nervous system, as endocrine hormones must first be synthesized, transported to their target cell, and enter or signal the cell. However, although hormones act more slowly than a nervous impulse, their effects are typically longer lasting.

Additionally, the target cells can respond to minute quantities of hormones and are sensitive to subtle changes in hormone concentration. For example, the growth hormones secreted by the pituitary gland are responsible for sustained growth during childhood.

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The endocrine system is made up of glands that make hormones. Hormones are the body's chemical messengers. They carry information and instructions from one set of cells to another.

The endocrine (pronounced: EN-duh-krin) system influences almost every cell, organ, and function of our bodies.

What Does the Endocrine System Do?

  • Endocrine glands release into the bloodstream. This lets the hormones travel to cells in other parts of the body.
  • The endocrine hormones help control mood, growth and development, the way our organs work, , and reproduction.
  • The endocrine system regulates how much of each hormone is released. This can depend on levels of hormones already in the blood, or on levels of other substances in the blood, like calcium. Many things affect hormone levels, such as stress, infection, and changes in the balance of fluid and minerals in blood.

Too much or too little of any hormone can harm the body. Medicines can treat many of these problems.

What Are the Parts of the Endocrine System?

While many parts of the body make hormones, the major glands that make up the endocrine system are the:

  • hypothalamus
  • pituitary
  • thyroid
  • parathyroids
  • adrenals
  • pineal body
  • the ovaries
  • the testes

The pancreas is part of the endocrine system and the digestive system. That's because it secretes hormones into the bloodstream, and makes and secretes enzymes into the digestive tract.

Hypothalamus: The hypothalamus (pronounced: hi-po-THAL-uh-mus) is in the lower central part of the brain. It links the endocrine system and nervous system. Nerve cells in the hypothalamus make chemicals that control the release of hormones secreted from the pituitary gland. The hypothalamus gathers information sensed by the brain (such as the surrounding temperature, light exposure, and feelings) and sends it to the pituitary. This information influences the hormones that the pituitary makes and releases.

Pituitary: The pituitary (pronounced: puh-TOO-uh-ter-ee) gland is at the base of the brain, and is no bigger than a pea. Despite its small size, the pituitary is often called the "master gland." The hormones it makes control many other endocrine glands.

The pituitary gland makes many hormones, such as:

  • growth hormone, which stimulates the growth of bone and other body tissues and plays a role in the body's handling of nutrients and minerals
  • prolactin (pronounced: pro-LAK-tin), which activates milk production in women who are breastfeeding
  • thyrotropin (pronounced: thy-ruh-TRO-pin), which stimulates the thyroid gland to make thyroid hormones
  • corticotropin (pronounced: kor-tih-ko-TRO-pin), which stimulates the adrenal gland to make certain hormones
  • antidiuretic (pronounced: an-ty-dy-uh-REH-tik) hormone, which helps control body water balance through its effect on the kidneys
  • oxytocin (pronounced: ahk-see-TOE-sin), which triggers the contractions of the uterus that happen during labor

The pituitary also secretes endorphins (pronounced: en-DOR-fins), chemicals that act on the nervous system and reduce feelings of pain. The pituitary also secretes hormones that signal the reproductive organs to make sex hormones. The pituitary gland also controls and the menstrual cycle in women.

Thyroid: The thyroid (pronounced: THY-royd) is in the front part of the lower neck. It's shaped like a bow tie or butterfly. It makes the thyroid hormones thyroxine (pronounced: thy-RAHK-sin) and triiodothyronine (pronounced: try-eye-oh-doe-THY-ruh-neen). These hormones control the rate at which cells burn fuels from food to make energy. The more thyroid hormone there is in the bloodstream, the faster chemical reactions happen in the body.

Thyroid hormones are important because they help kids' and teens' bones grow and develop, and they also play a role in the development of the brain and nervous system.

Parathyroids: Attached to the thyroid are four tiny glands that work together called the parathyroids (pronounced: par-uh-THY-roydz). They release parathyroid hormone, which controls the level of calcium in the blood with the help of calcitonin (pronounced: kal-suh-TOE-nin), which the thyroid makes.

Adrenal Glands: These two triangular adrenal (pronounced: uh-DREE-nul) glands sit on top of each kidney. The adrenal glands have two parts, each of which makes a set of hormones and has a different function:

  1. The outer part is the adrenal cortex. It makes hormones called corticosteroids (pronounced: kor-tih-ko-STER-oydz) that help control salt and water balance in the body, the body's response to stress, metabolism, the immune system, and sexual development and function.
  2. The inner part is the adrenal medulla (pronounced: muh-DUH-luh). It makes catecholamines (pronounced: kah-tuh-KO-luh-meenz), such as epinephrine (pronounced: eh-puh-NEH-frun). Also called adrenaline, epinephrine increases blood pressure and heart rate when the body is under stress.

Pineal: The pineal (pronounced: pih-NEE-ul) body, also called the pineal gland, is in the middle of the brain. It secretes melatonin (pronounced: meh-luh-TOE-nin), a hormone that may help regulate when you sleep at night and when you wake in the morning.

Reproductive Glands: The gonads are the main source of sex hormones. Most people don't realize it, but both guys and girls have gonads. In guys the male gonads, or testes (pronounced: TES-teez), are in the scrotum. They secrete hormones called androgens (pronounced: AN-druh-junz), the most important of which is (pronounced: tess-TOSS-tuh-rone). These hormones tell a guy's body when it's time to make the changes associated with puberty, like penis and height growth, deepening voice, and growth in facial and pubic hair. Working with hormones from the pituitary gland, testosterone also tells a guy's body when it's time to make sperm in the testes.

A girl's gonads, the ovaries (pronounced: OH-vuh-reez), are in her pelvis. They make eggs and secrete the female hormones (pronounced: ESS-truh-jen) and (pronounced: pro-JESS-tuh-rone). Estrogen is involved when a girl starts puberty. During puberty, a girl will have breast growth, start to accumulate body fat around the hips and thighs, and have a growth spurt. Estrogen and progesterone are also involved in the regulation of a girl's menstrual cycle. These hormones also play a role in pregnancy.

Pancreas: The pancreas (pronounced: PAN-kree-us) makes insulin (pronounced: IN-suh-lin) and glucagon (pronounced: GLOO-kuh-gawn), which are hormones that control the level of glucose, or sugar, in the blood. Insulin helps keep the body supplied with stores of energy. The body uses this stored energy for exercise and activity, and it also helps organs work as they should.

How Can I Help Keep My Endocrine System Healthy?

To help keep your endocrine system healthy:

  • Get plenty of exercise.
  • Eat a nutritious diet.
  • Go for regular medical checkups.
  • Talk to the doctor before taking any supplements or herbal treatments.
  • Let the doctor know about any family history of endocrine problems, such as diabetes or thyroid problems.

When Should I Call the Doctor?

Let the doctor know if you:

  • drink a lot of water but are still thirsty
  • have to pee often
  • have frequent belly pain or nausea
  • are very tired or weak
  • are gaining or losing a lot of weight
  • have tremors or sweat a lot
  • are constipated
  • are not growing or developing as expected