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Clinical Examples of Geriatric Assessment Metrics

DomainMetric ExampleClinical Conclusion
FunctionSPPB26Impaired SPPB is associated with a twofold higher risk of death compared with those with a normal physical performance among populations with leukemia27
TUGPoor mobility by TUG predicts early mortality among cancer populations
Handgrip strength28Grip strength is an accurate and consistent predictor of all causes of mortality in middle-aged and elderly persons (RR, 0.89)29
Brief Fatigue Inventory30Fatigue strongly correlates with depression and is highly variable post-transplant39
ADL/IADLDeficits in ADL, combined with age and comorbidities among patients with MM, resulted in notable survival differences in patients21
PsychiatricHADS31Psychiatric morbidity results in a significantly longer length of hospital stay and influences recovery post-transplant32
SocialMOS Social Support Survey31Social isolation and loneliness predict disease outcome and results in substantial impairment in psychologic and physical well-being33
Social support structure impacts clinical outcomes and quality of life post-transplant.34,35
3MSCognitive impairment demonstrates the greatest likelihood for mortality among older adults with leukemia27
Attention deficits persist for up to a year following myeloma transplant36
NutritionMNAImpaired nutritional status independently predicts early death in patients with newly diagnosed cancer at age 65 or older (OR, 2.77).
ComorbiditiesComorbidity calculator38HCT-CI predicts nonrelapse mortality and survival in MM37,38