Holmes, E., Wilson, I. D. & Nicholson, J. K. Metabolic phenotyping in health and disease. Cell 134, 714–717 (2008).
CAS PubMed Article Google Scholar
Wu, D. et al. Plasma metabolomic and lipidomic alterations associated with COVID-19. Natl. Sci. Rev. 7, 1157–1168 (2020).
CAS Article Google Scholar
Shen, B. et al. Proteomic and metabolomic characterization of COVID-19 patient sera. Cell 182, 59–72 (2020).
CAS PubMed PubMed Central Article Google Scholar
Song, J.-W. et al. Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis. Cell Met. 32, 188–202 (2020).
CAS Article Google Scholar
Barberis, E. et al. Large-scale plasma analysis revealed new mechanisms and molecules associated with the host response to SARS-CoV-2. Int. J. Mol. Sci. 21, 8623 (2020).
CAS PubMed Central Article PubMed Google Scholar
Barberis, E. et al. Circulating exosomes are strongly involved in SARS-CoV-2 infection. Front. Mol. Biosci. https://doi.org/10.3389/fmolb.2021.632290 (2021).
Article PubMed PubMed Central Google Scholar
Nightingale Health UK Biobank Initiative, Julkunen, H., Cichonska, Slagboom, P. E. & Wurtz, P. Blood biomarker score identifies individuals at high for severe COVID-19 a decade prior to diagnosis: Metabolic profiling of 105,000 adults in the UK biobank. medRxiv. https://doi.org/10.1101/2020.07.02.20143685 (2020).
Zivkovic, A. M. & German, J. B. Metabolomics for assessment of nutritional status. Curr. Opin. Clin. Nutr. Met. Care 12, 501–507 (2009).
CAS Article Google Scholar
Guasch-Ferré, M., Bhupathiaraju, S. N. & Hu, F. B. Use of metabolomics in improving assessment of dietary intake. Clin. Chem. 64, 82–98 (2018).
PubMed Article CAS Google Scholar
Mayneris-Perxachs, J. & Swann, J. R. Metabolic phenotyping of malnutrition during the first 1000 days of life. Eur. J. Nut. 58, 909–930 (2018).
Article CAS Google Scholar
Di Matteo, G. et al. Food and COVID-19: Preventive/co-therapeutic strategies explored by current clinical trials and silico studies. Foods 9, 1036 (2020).
PubMed Central Article CAS Google Scholar
Sahebnasagh, A. et al. The prophylaxis and treatment potential of supplements for COVID-19. Eur. J. Pharm. 887, 173530 (2020).
CAS Article Google Scholar
Infusino, F. et al. Diet supplementation, probiotics, and nutraceuticals in SARS-CoV-2 infection: A scoping review. Nutrients 12, 1718 (2020).
CAS PubMed Central Article Google Scholar
Singh, P. et al. Potential inhibitors SARS-CoV-2 and functional food components as nutritionals supplement for COVID-19: A review. Plant Foods Hum. Nutr. 75, 458–466 (2020).
PubMed Article CAS Google Scholar
Soliman, S., Faris, M. E., Ratemi, Z. & Halwani, R. Switching host metabolism as an approach to dampen SARS-CoV-2 infection. Ann. Nutr. Met. 76, 297–303 (2020).
CAS Article Google Scholar
Louca, P. et al. Dietary supplemetns duringthe COVID-19 pandemic: Insights from 1,4M users of the COVID symptom study app—A longitudinal app-based community survey. medRxiv https://doi.org/10.1101/2020.11.27.20239087 (2020).
Article Google Scholar
Kabara, J. J. Fatty acids and derivatives as antimicrobial agents: A review. In Symp. on The Pharmacological Effect of Lipids. (ed. Kabara J.J.) (The American Oil Chemists’ Society, Champaign, IL, 1978).
Hierholzer, J. C. & Kabara, J. J. In vitro effects of monolaurin compounds on enveloped RNA and DNA viruses. J. Food Saf. 4, 1–12 (1982).
CAS PubMed PubMed Central Article Google Scholar
Anang, D. M., Rusul, G., Bakar, J. & Ling, F. H. Effects of lactic acid lauricidin on the survival of Listeria monocytogenes, Salmonella enteritidis and Escherichia coli O157:H7 in chicken breast stored a 4 °C. Food Control 18, 961–969 (2006).
Article CAS Google Scholar
Hornung, B., Amtmann, E. & Sauer, G. Lauric acid inhibits the maturation of vescicular stomatitis virus. J. Gen. Vir. 75, 353–361 (1994).
CAS Article Google Scholar
Yeap, S. K. et al. Antistress and antioxidant effects of virgin coconut oil in vivo. Exp. Ther. Med. 9, 39–42 (2014).
PubMed PubMed Central Article CAS Google Scholar
Akinnuga, A. M., Jeje, S. O., Bamidele, O. & Sunday, V. E. Dietary consumption of virgin coconut oil ameliorates lipid profiles in diabetics rats. Physiol. J. https://doi.org/10.1155/2014/256236 (2014).
Article Google Scholar
Abujazia, M. A., Muhammad, N., Shuiid, A. N. & Soelaiman, I. N. The effects of virgi coconut oil on bone oxidative status in ovariectomised rat. Evid. Based Complem. Altern. Med. https://doi.org/10.1155/2012/525079 (2012).
Article Google Scholar
Thormar, H., Isaacs, C. E., Brown, H. R., Barshatzky, M. R. & Pessolano, T. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob. Agents Chemother. 31, 27–31 (1987).
CAS PubMed PubMed Central Article Google Scholar
Bartolotta, S., Garcìa, C. C., Camdurra, N. A. & Damonte, E. B. Effects of fatty acids on arenavirus replication: Inhibition of virus production by lauric acid. Arch. Virol. 146, 777–790 (2001).
CAS PubMed Article PubMed Central Google Scholar
Grant, A. et al. Junìn virus pathogenesis and virus replication. Viruses 4, 2317–2339 (2012).
CAS PubMed PubMed Central Article Google Scholar
Yan, B. et al. Characterization of the lipidomic profile of human coronavirus-infected cells: Implications for lipid metabolism remodeling upon coronavirus replication. Viruses 11, 73 (2019).
CAS PubMed Central Article Google Scholar
Hannah, M. A. et al. Intermittent fasting, a possible priming tool for host defense against SARA-CoV-2: Crosstalk among calorie restriction, autophagy and immune response. Immunol. Lett. 226, 38–45 (2020).
Article CAS Google Scholar
Yuniwarti, E. Y. W., Asmara, W., Artama, W. T. & Tabbu, C. R. The effect of virgin coconut oil on lymphocyte and CD4 in chicken vaccinated against avian influenza virus. J. Indonesian Trop. Anim. Agric. 37, 64–69 (2012).
Article Google Scholar
Zhang, M., Sandouk, A. & Houtman, J. C. D. Glycerol monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics. Sci. Rep. 6, 30225 (2016).
ADS CAS PubMed PubMed Central Article Google Scholar
Strunk, T. et al. Topical coconut oil contributes to systemic monolaurin levels in very preterm infants. Neonatology 116, 299–301 (2019).
PubMed Article Google Scholar
Ren, C. et al. A combination of formic acid and monolaurin attenuates enteroxigenic the NF-kB/MAPK pathways with modulation of gut microbiota. J. Agric. Food Chem 68, 4155–4165 (2020).
CAS PubMed Article Google Scholar
Trisnawati, I. Virgin coconut oil (VCO) as a potential adjuvant therapy in COVID-19 patients. https://clinicaltrials.gov/ct2/show/NCT04594330 (2020).
Lee, E. H. et al. Diagnosis and mortality prediction of sepsis via lysophosphatidylcholine 16:0 measured by MALDI-TOF MS. Sci. Rep. 10, 13833 (2020).
CAS PubMed PubMed Central Article Google Scholar
Katsiki, N., Banch, M. & Mikhailidis, D. P. Lipid-lowering therapy and renin-angiotensin-aldosterone system ignitors in the era of the COVID-19. Arch. Med. Sci. 16, 485–489 (2020).
CAS PubMed PubMed Central Article Google Scholar
Wang, D. et al. Clinical characteristics of hospitalized patients with 2019 novel-coronavirus-infected pneumonia in Wuhan, China. JAMA 323, 1061–1069 (2020).
CAS PubMed PubMed Central Article Google Scholar
Lu, Y., Liu, D. X. & Tam, J. P. Lipid rafts are involved in SARS-CoV entry into Vero E6 cells. Biochem. Biophys. Res. Commun. 369, 344–349 (2008).
CAS PubMed PubMed Central Article Google Scholar
Choi, K. S., Aizaki, H. & Lai, M. M. C. Murine coronavirus requires lipid rafts for virus entry and cell-cell fusion but not for virus release. J. Virol. 79, 9862–9871 (2005).
CAS PubMed PubMed Central Article Google Scholar
Guo, H. et al. The important role of lipid raft-mediated attachment in the infection of cultured cells by coronavirus infectious bronchitis virus Beaudette strain. PLoS ONE 12, e0170123 (2017).
PubMed PubMed Central Article CAS Google Scholar
Jeon, J. H. & Lee, C. Cholesterol is important for the entry process of porcine deltacoronavirus. Arch. Virol. 163, 3119–3124 (2018).
CAS PubMed PubMed Central Article Google Scholar
Li, G.-M., Li, Y.-G., Yamate, M., Li, S.-M. & Ikuta, K. Lipidrafts play an important role in the early stage of severe acute respiratory syndrome-coronavirus life cycle. Microb. Infect. 9, 96–102 (2006).
Article CAS Google Scholar
Katsiki, N., Banach, M. & Mikhailidis, D. P. Lipid-lowering therapy and renin-angiotensin-aldosterone system inhibitors in the era of COVID-19 pandemic. Arch. Med. Sci. 16, 485–489 (2020).
CAS PubMed PubMed Central Article Google Scholar
Baglivo, M. et al. Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: A possible strategy for reducing SARS-CoV-2 infectivity?. Acta Biomed. 91, 161–164 (2020).
PubMed PubMed Central Google Scholar
Vittiello, A., La porta, R. & Ferrara, F. Correlation between the use of statins and COVID-19: what do we know?. BMJ Evid.-Based-Med. 0, 1–2 (2020).
Google Scholar
Tan, W. Y. T., Young, B. E., Lye, D. C., Chew, D. E. K. & Dalan, R. Statin use is associated with lower disease severity in COVID-19 infection. Sci. Rep. 10, 17458 (2020).
ADS CAS PubMed PubMed Central Article Google Scholar
Daniels, L. B. et al. Relation of statin use prior to admission to severity and recovery among COIVD-19 inpatients. Am. J. Cardiol 136, 149–155 (2020).
CAS PubMed PubMed Central Article Google Scholar
Novack, V. et al. The effects of stain therapy on inflammatory cytokines in patients with bacterial infection: A randomized double-blind placebo controlled clinical trial. Intensive Care Med. 35, 1255–1260 (2009).
CAS PubMed Article Google Scholar
Mortensen, E. M., Restrepo, M., Anzueto, A. & Pugh, J. The effects of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumonia. Respir. Res. 6, 82 (2005).
PubMed PubMed Central Article CAS Google Scholar
Vandermeer, M. et al. Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: A multistate study. J. Infect. Dis. 205, 13–19 (2012).
CAS PubMed Article Google Scholar
Castiglione, V., Chiriacò, M., Emdin, M., Taddei, S. & Vergaro, G. Statin therapy in COVID-19 infection. Eur. Heart J. Cardiovasc. Pharmacother. 6, 258–259 (2020).
PubMed Article PubMed Central Google Scholar
Reiner, Z. et al. Statins and the COVID-19 main protease: In silico evidence on direct interaction. Arch. Med. Sci. 16, 490–496 (2020).
CAS PubMed PubMed Central Article Google Scholar
Bruzzone, C. et al. SARS-CoV-2 infection dysregulates the metabolomic and lipidomic profiles of serum. iScience 23, 101645 (2020).
ADS CAS PubMed PubMed Central Article Google Scholar
Huang, W. et al. Decreased serum albumin level indicates poor prognosis: Hepatic injury analysis from 2623 hospitalized case. Sci. China Life Sci. 63, 1–10 (2020).
ADS PubMed PubMed Central Google Scholar
Wang, S. et al. Cholesterol 25-hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol. Embo J. 39, e106057 (2020).
CAS PubMed PubMed Central Google Scholar
Casari, I., Manfredi, M., Metharom, P. & Falasca, M. Dissecting lipid metabolism alterations in SARS-CoV-2. Prog. Lip. Res. 82, 101092 (2021).
CAS Article Google Scholar
Lee, W. et al. COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokines storm. Signal Transduct. Target. Ther. 5, 186 (2020).
CAS PubMed PubMed Central Article Google Scholar
Mir, A. B., Islam, K. & Khan, A.-A.-K. Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy. Sci. Rep. 10, 19395 (2020).
ADS Article CAS Google Scholar
Kendall, R.V. & Lawson, J.W. Dimethylglycine Enhancement of antibody production. US Patent 5,118,618 (1992).
Wang, C. & Lawson J. The Effects on the Enhancement of Monoclonal Antibody Production. In Annual Meeting of the American Society of Microbiology (1988).
Barberis, E. et al. Leonardo’s Donna Nuda unveiled. J. Proteom. 207, 103450 (2019).
CAS Article Google Scholar
Manfredi, M. et al. Integrated serum proteins and fatty acids analysis for putative biomarker discovery in inflammatory bowel disease. J. Proteom. 195, 138–149 (2019).