Prenatal ultrasonography can detect changes in utero suggestive of cystic fibrosis and meconium ileus (eg, dilated bowel, polyhydramnios), but these changes are not specific.
Diagnosis of meconium ileus is suspected in a neonate with signs of intestinal obstruction, particularly if a family history of cystic fibrosis exists. Patients should undergo abdominal x-rays, which show dilated intestinal loops; however, fluid levels may be absent. A “soap bubble” or “ground glass” appearance due to small air bubbles mixed with the meconium is diagnostic of meconium ileus. If meconium peritonitis is present, calcified meconium flecks may line the peritoneal surfaces and even the scrotum. A water-soluble contrast enema reveals a microcolon with an obstruction in the terminal ileum.
Answer: mucoviscidosis, meconium or obstruction Explanation: Mecomium in mucoviscidosis or cystic fibrosis is an condition that relates to the presence of mecomium in the digested food tract Mucoviscidosis or cystic fibrosis is an ailment that relates to the sweat, digestive juices, producing cells located in pancrease, lungs Mecomium is the stool formed from materials taken by the baby while in the uterus consisting of intestinal cells, lanugo, amniotic fluid, bile.
For the statement "intestinal obstruction due to meconium in mucoviscidosis of newborn," the main term to reference in the ICD-10-CM Index to Diseases and Injuries is . Meconium is the first stool (bowel movement) that a newborn has. This stool is very thick and sticky. Meconium ileus is a bowel obstruction that occurs when the meconium in your child's intestine is even thicker and stickier than normal meconium, creating a blockage in a part of the small intestine called the ileum. Most infants with meconium ileus have a disease called cystic fibrosis. The earliest signs of meconium ileus are abdominal distention (a swollen belly), bilious (green) vomit and no passage of meconium. Your child's doctor will order an X-ray of your child's abdomen to find out if she has meconium in her intestines. If a doctor suspects that your child has a meconium ileus, she won't be given anything to eat or drink and will be fed through an intravenous (IV) line, a small tube that's inserted into a vein. A small tube — called a nasogastric (NG) tube — will also be placed through your child's nose and passed into her stomach to help remove excess air and fluid. The medical team may try to break up the meconium blockage with medicines given to your child through an enema. If the medicine doesn't break up the meconium, she may need surgery. If your baby needs surgery for meconium ileus, she'll have a bowel resection and ileostomy placement. Bowel resection surgeryYour child may need a bowel resection, a surgical procedure that brings part of the small intestine out to the surface of the abdominal wall. This creates an ileostomy, which is temporary. The bowel can be reconnected once your child's ileus is gone. After the operation, your child will go to the Newborn/Infant Intensive Care Unit (N/IICU). Your child will have a small incision on her abdomen, which will be covered with a gauze dressing. She'll also have an NG tube to help empty her stomach. Your child may have an ileostomy. You will learn how to care for the ileostomy before leaving the hospital. Your baby's healthcare team will give her pain medication, as needed. When your child first comes back to her room after surgery, she'll need narcotic medications, such as morphine or Versed, which she'll get through her IV. After a few days, acetaminophen (TYLENOL) should relieve her pain. Your child will also receive antibiotics after surgery to prevent infection. Your child will be ready to go home when her incisions are healing nicely, she doesn't have a fever, and is able to drink, urinate and have a bowel movement. This is usually in one to two weeks. Once your baby is home, she may drink formula or breast milk. You can give her acetaminophen (TYLENOL) — according to her doctor's instructions — to relieve any pain she's experiencing. The thin tapes over the incision (called STERI-STRIPS) will fall off on their own. Your child can have a tub bath one week after surgery. Be sure to call your child's doctor if:
Meconium ileus equivalent (MIE) complicating cystic fibrosis of the pancreas (CF) increases in frequently with increasing age of patients. In the present paper the course of 11 children and adolescents with MIE diagnosed and treated at the University Dept. of Paediatrics in Zürich during the last 15 years, i.e. 9% of 120 CF patients, is analyzed. 9 were successfully managed by medical treatment alone, 1 three months old infant was treated surgically with no later relapse and a 26 years old patient with a chronic deleterious course leading to opiate dependency could be relieved only by ileostomy. 5 patients experienced only 1 episode of MIE, 2- two to three and in 4 a chronic refractory course with multiple episodes was probably due to an inadequate medical management. The evaluation of the events in our patients and of the available data from the literature allows the following conclusions: MIE is a preventable condition in CF patients; a rigorous medical treatment of exocrine pancreatic insufficiency supplemented with mucolytic agents orally can usually prevent MIE and relieve an established MIE; surgical treatments is indicated only in desperate situations.
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Two newborns with intestinal obstruction of the terminal ileum without mucoviscidosis were cured by Gastrografin enema. A further case of a premature infant showed, at autopsy, a large intestine containing normal meconium, but an ileum which was plugged with tenacious meconium containing PAS-positive and alcian blue-negative mucus. Our 3 cases were similar to cases of "meconium disease" reported by Rickham and of "meconium plug in the small intestine" reported by Emery. The primary cause of this disease lies in the large amount of PAS-positive mucus secreted from goblet cells of the ileal mucosa and the hypertrophy of lymph nodules in the ileal submucosa.
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