What is the process by which neutrophils and golf bacteria viruses and other cellular debris?

1. Ley K, et al. Neutrophils: new insights and open questions. Sci. Immunol. 2018;3:eaat4579. [PubMed] [Google Scholar]

2. Summers C, et al. Neutrophil kinetics in health and disease. Trends Immunol. 2010;31:318–324. [PMC free article] [PubMed] [Google Scholar]

3. Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat. Rev. Immunol. 2013;13:159–175. [PubMed] [Google Scholar]

4. Cheemarla NR, Baños-Lara MDR, Naidu S, Guerrero-Plata A. Neutrophils regulate the lung inflammatory response via γδ T cell infiltration in an experimental mouse model of human metapneumovirus infection. J. Leukoc. Biol. 2017;101:1383–1392. [PMC free article] [PubMed] [Google Scholar]

5. Soto JA, et al. Human metapneumovirus: mechanisms and molecular targets used by the virus to avoid the immune system. Front. Immunol. 2018;9:2466. [PMC free article] [PubMed] [Google Scholar]

6. Darniot M, Petrella T, Aho S, Pothier P, Manoha C. Immune response and alteration of pulmonary function after primary human metapneumovirus (hMPV) infection of BALB/c mice. Vaccine. 2005;23:4473–4480. [PubMed] [Google Scholar]

7. Kirsebom FCM, Kausar F, Nuriev R, Makris S, Johansson C. Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection. Mucosal Immunol. 2019;12:1244–1255. [PMC free article] [PubMed] [Google Scholar]

8. Goritzka M, et al. Interferon-α/β receptor signaling amplifies early pro-inflammatory cytokine production in the lung during respiratory syncytial virus infection. J. Virol. 2014;88:6128–6136. [PMC free article] [PubMed] [Google Scholar]

9. Goritzka M, et al. Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes. J. Exp. Med. 2015;212:699–714. [PMC free article] [PubMed] [Google Scholar]

10. McNamara PS, Ritson P, Selby A, Hart CA, Smyth RL. Bronchoalveolar lavage cellularity in infants with severe respiratory syncytial virus bronchiolitis. Arch. Dis. Child. 2003;88:922–926. [PMC free article] [PubMed] [Google Scholar]

11. Everard ML, et al. Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection. Arch. Dis. Child. 1994;71:428–432. [PMC free article] [PubMed] [Google Scholar]

12. Totura AL, et al. Toll-like receptor 3 signaling via TRIF contributes to a protective innate immune response to severe acute respiratory syndrome coronavirus infection. MBio. 2015;6:e00638-15. [PMC free article] [PubMed] [Google Scholar]

13. Haick AK, Rzepka JP, Brandon E, Balemba OB, Miura TA. Neutrophils are needed for an effective immune response against pulmonary rat coronavirus infection, but also contribute to pathology. J. Gen. Virol. 2014;95:578–590. [PMC free article] [PubMed] [Google Scholar]

14. Middleton EA, et al. Neutrophil extracellular traps (NETs) contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood. 2020;136:1169–1179. [PMC free article] [PubMed] [Google Scholar]

15. Channappanavar R, et al. Sex-based differences in susceptibility to severe acute respiratory syndrome coronavirus infection. J. Immunol. 2017;198:4046–4053. [PMC free article] [PubMed] [Google Scholar]

16. Zhou Z, et al. Heightened innate immune responses in the respiratory tract of COVID-19 patients. Cell Host Microbe. 2020;27:883–890. [PMC free article] [PubMed] [Google Scholar]

17. Winkler ES, et al. SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function. Nat. Immunol. 2020;181:1–21. [PMC free article] [PubMed] [Google Scholar]

18. Nagarkar DR, et al. CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection. J. Immunol. 2009;183:6698–6707. [PMC free article] [PubMed] [Google Scholar]

19. Berman R, et al. MUC18 regulates lung rhinovirus infection and inflammation. PLoS ONE. 2016;11:e0163927–13. [PMC free article] [PubMed] [Google Scholar]

20. Winther B. Rhinovirus infections in the upper airway. Proc. Am. Thorac. Soc. 2011;8:79–89. [PubMed] [Google Scholar]

21. Mallia P, Message SD, Contoli M. Neutrophil adhesion molecules in experimental rhinovirus infection in COPD. Respir. Res. 2013;14:1–9. [PMC free article] [PubMed] [Google Scholar]

22. Jarjour NN, et al. The effect of an experimental rhinovirus 16 infection on bronchial lavage neutrophils. JACI. 2000;105:1169–1177. [PubMed] [Google Scholar]

23. Young Yull K, et al. Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans. Chest. 2015;131:1454–1460. [PubMed] [Google Scholar]

24. Cortjens B, Lutter R, Boon L, Bem RA, van Woensel JBM. Pneumovirus-induced lung disease in mice is independent of neutrophil-driven inflammation. PLoS ONE. 2016;11:e0168779. [PMC free article] [PubMed] [Google Scholar]

25. McCarthy MK, Zhu L, Procario MC, Weinberg JB. IL-17 contributes to neutrophil recruitment but not to control of viral replication during acute mouse adenovirus type 1 respiratory infection. Virology. 2014;456–457:259–267. [PMC free article] [PubMed] [Google Scholar]

26. Wu W, et al. Human lung innate immune cytokine response to adenovirus type 7. J. Gen. Virol. 2010;91:1155–1163. [PMC free article] [PubMed] [Google Scholar]

27. Stacey MA, et al. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host Microbe. 2014;15:471–483. [PMC free article] [PubMed] [Google Scholar]

28. Camp JV, Jonsson CB. A role for neutrophils in viral respiratory disease. Front. Immunol. 2017;8:11–17. [PMC free article] [PubMed] [Google Scholar]

29. Galani IE, Andreakos E. Neutrophils in viral infections: current concepts and caveats. J. Leukoc. Biol. 2015;98:557–564. [PubMed] [Google Scholar]

30. Schönrich G, Raftery MJ. Neutrophil extracellular traps go viral. Front. Immunol. 2016;7:526–527. [PMC free article] [PubMed] [Google Scholar]

31. Marguet C, et al. Neutrophil but not eosinophil inflammation is related to the severity of a first acute epidemic bronchiolitis in young infants. Pediatr. Allergy Immunol. 2008;19:157–165. [PubMed] [Google Scholar]

32. Lukens MV, et al. A systemic neutrophil response precedes robust CD8(+) T-cell activation during natural respiratory syncytial virus infection in infants. J. Virol. 2010;84:2374–2383. [PMC free article] [PubMed] [Google Scholar]

33. Cavallaro EC, Liang K-K, Lawrence MD, Forsyth KD, Dixon D-L. Neutrophil infiltration and activation in bronchiolitic airways are independent of viral etiology. Pediatr. Pulmonol. 2017;52:238–246. [PubMed] [Google Scholar]

34. Tang BM, et al. Neutrophils-related host factors associated with severe disease and fatality in patients with influenza infection. Nat. Commun. 2019;10:1–13. [PMC free article] [PubMed] [Google Scholar]

35. Zuo Y, et al. Neutrophil extracellular traps in COVID-19. JCI Insight. 2020;5:e138999. [PMC free article] [PubMed] [Google Scholar]

36. Xiong Y, et al. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Emerg. Microbes Infect. 2020;9:761–770. [PMC free article] [PubMed] [Google Scholar]

37. Wong P, et al. Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature. 2020;584:463–469. [PMC free article] [PubMed] [Google Scholar]

38. Mejias A, et al. Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection. PLoS Med. 2013;10:e1001549. [PMC free article] [PubMed] [Google Scholar]

39. Dunning J, et al. Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nat. Immunol. 2018;19:625–635. [PMC free article] [PubMed] [Google Scholar]

40. Meizlish ML, et al. A neutrophil activation signature predicts critical illness and mortality in COVID-19. Blood Adv. 2021;5:1164–1177. [PMC free article] [PubMed] [Google Scholar]

41. van den Brand JMA, et al. Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets. PLoS ONE. 2012;7:e42343-21. [PMC free article] [PubMed] [Google Scholar]

42. Hägglund S, et al. Proteome analysis of bronchoalveolar lavage from calves infected with bovine respiratory syncytial virus—insights in pathogenesis and perspectives for new treatments. PLoS ONE. 2017;12:e0186594-19. [PMC free article] [PubMed] [Google Scholar]

43. Cortjens B, et al. Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease. J. Pathol. 2015;238:401–411. [PubMed] [Google Scholar]

44. Tate MD, et al. Neutrophils ameliorate lung injury and the development of severe disease during influenza infection. J. Immunol. 2009;183:7441–7450. [PubMed] [Google Scholar]

45. Nicolás-Ávila JÁ, Adrover JM, Hidalgo A. Neutrophils in homeostasis, immunity, and cancer. Immunity. 2017;46:15–28. [PubMed] [Google Scholar]

46. Kreisel D, et al. In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation. Proc. Natl Acad. Sci. USA. 2010;107:18073–18078. [PMC free article] [PubMed] [Google Scholar]

47. Devi S, et al. Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J. Exp. Med. 2013;210:2321–2336. [PMC free article] [PubMed] [Google Scholar]

48. Williams MR, Azcutia V, Newton G, Alcaide P, Luscinskas FW. Emerging mechanisms of neutrophil recruitment across endothelium. Trends Immunol. 2011;32:461–469. [PMC free article] [PubMed] [Google Scholar]

49. Pittman K, Kubes P. Damage-associated molecular patterns control neutrophil recruitment. J. Innate Immun. 2013;5:315–323. [PMC free article] [PubMed] [Google Scholar]

50. Nuriev R, Johansson C. Chemokine regulation of inflammation during respiratory syncytial virus infection. F1000Res. 2019;8:1–11. [PMC free article] [PubMed] [Google Scholar]

51. Petri B, Sanz M-J. Neutrophil chemotaxis. Cell Tissue Res. 2018;371:425–436. [PubMed] [Google Scholar]

52. Sadik CD, Kim ND, Luster AD. Neutrophils cascading their way to inflammation. Trends Immunol. 2011;32:452–460. [PMC free article] [PubMed] [Google Scholar]

53. Ley K. Integration of inflammatory signals by rolling neutrophils. Immunol. Rev. 2002;186:8–18. [PubMed] [Google Scholar]

54. Stoppelenburg AJ, et al. Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection. PLoS ONE. 2013;8:e78461. [PMC free article] [PubMed] [Google Scholar]

55. Li H, et al. Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. PLoS Pathog. 2018;14:e1006821. [PMC free article] [PubMed] [Google Scholar]

56. Noah TL, Becker S. Chemokines in nasal secretions of normal adults experimentally infected with respiratory syncytial virus. Clin. Immunol. 2000;97:43–49. [PubMed] [Google Scholar]

57. Booth JL, Coggeshall KM, Gordon BE, Metcalf JP. Adenovirus type 7 induces interleukin-8 in a lung slice model and requires activation of Erk. J. Virol. 2004;78:4156–4164. [PMC free article] [PubMed] [Google Scholar]

58. Peiró T, et al. Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection. Thorax. 2017;73:546–556. [PMC free article] [PubMed] [Google Scholar]

59. Tate MD, Brooks AG, Reading PC. The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice. Respir. Res. 2008;9:57. [PMC free article] [PubMed] [Google Scholar]

60. Camp JV, et al. Lower respiratory tract infection of the ferret by 2009 H1N1 pandemic influenza a virus triggers biphasic, systemic, and local recruitment of neutrophils. J. Virol. 2015;89:8733–8748. [PMC free article] [PubMed] [Google Scholar]

61. Durant LR, et al. DNGR-1 is dispensable for CD8(+) T-cell priming during respiratory syncytial virus infection. Eur. J. Immunol. 2014;44:2340–2348. [PubMed] [Google Scholar]

62. Perrone LA, Plowden JK, García-Sastre A, Katz JM, Tumpey TM. H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog. 2008;4:e1000115–11. [PMC free article] [PubMed] [Google Scholar]

63. Rudd JM, et al. Neutrophils induce a novel chemokine receptors repertoire during influenza pneumonia. Front. Cell. Infect. Microbiol. 2019;9:1393–12. [PMC free article] [PubMed] [Google Scholar]

64. Bradley LM, Douglass MF, Chatterjee D, Akira S, Baaten BJG. Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling. PLoS Pathog. 2012;8:e1002641–12. [PMC free article] [PubMed] [Google Scholar]

65. Tate MD, et al. The role of neutrophils during mild and severe influenza virus infections of mice. PLoS ONE. 2011;6:e17618. [PMC free article] [PubMed] [Google Scholar]

66. Kulkarni U, et al. Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. Mucosal Immunol. 2019;12:545–554. [PMC free article] [PubMed] [Google Scholar]

67. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat. Immunol. 2010;11:373–384. [PubMed] [Google Scholar]

68. Chow KT, Gale M, Jr, Loo Y-M. RIG-I and other RNA sensors in antiviral immunity. Annu. Rev. Immunol. 2018;36:667–694. [PubMed] [Google Scholar]

69. Openshaw PJM, Chiu C, Culley FJ, Johansson C. Protective and harmful immunity to RSV infection. Annu. Rev. Immunol. 2017;35:501–532. [PubMed] [Google Scholar]

70. Iwasaki A, Pillai PS. Innate immunity to influenza virus infection. Nat. Rev. Immunol. 2014;14:315–328. [PMC free article] [PubMed] [Google Scholar]

71. Johansson C. Respiratory syncytial virus infection: an innate perspective. F1000Res. 2016;5:2898. [PMC free article] [PubMed] [Google Scholar]

72. Rudd BD, et al. MyD88-mediated instructive signals in dendritic cells regulate pulmonary immune responses during respiratory virus infection. J. Immunol. 2007;178:5820–5827. [PubMed] [Google Scholar]

73. Murawski MR, et al. Respiratory syncytial virus activates innate immunity through toll-like receptor 2. J. Virol. 2009;83:1492–1500. [PMC free article] [PubMed] [Google Scholar]

74. Goritzka M, Pereira C, Makris S, Durant LR, Johansson C. T cell responses are elicited against respiratory syncytial virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R. Sci. Rep. 2015;5:18533. [PMC free article] [PubMed] [Google Scholar]

75. Seo S-U, et al. MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection. J. Virol. 2010;84:12713–12722. [PMC free article] [PubMed] [Google Scholar]

76. Leung YHC, et al. Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in toll-like receptor 3 knockout mice. J. Gen. Virol. 2014;95:1870–1879. [PMC free article] [PubMed] [Google Scholar]

77. Sheahan T, et al. MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV. PLoS Pathog. 2008;4:e1000240–12. [PMC free article] [PubMed] [Google Scholar]

78. Le Goffic R, et al. Detrimental contribution of the toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS Pathog. 2006;2:e53. [PMC free article] [PubMed] [Google Scholar]

79. Cheemarla NR, Guerrero-Plata A. Human metapneumovirus attachment protein contributes to neutrophil recruitment into the airways of infected mice. Viruses. 2017;9:310. [PMC free article] [PubMed] [Google Scholar]

80. Miller AL, Bowlin TL, Lukacs NW. Respiratory syncytial virus-induced chemokine production: linking viral replication to chemokine production in vitro and in vivo. J. Infect. Dis. 2004;189:1419–1430. [PubMed] [Google Scholar]

81. Sengupta S, et al. Circadian control of lung inflammation in influenza infection. Nat. Commun. 2019;10:4107. [PMC free article] [PubMed] [Google Scholar]

82. You D, Siefker DT, Shrestha B, Saravia J, Cormier SA. Building a better neonatal mouse model to understand infant respiratory syncytial virus disease. Respir. Res. 2015;16:91. [PMC free article] [PubMed] [Google Scholar]

83. Das S, et al. Respiratory syncytial virus infection of newborn CX3CR1-deficent mice induces a pathogenic pulmonary innate immune response. JCI Insight. 2017;2:14–16. [PMC free article] [PubMed] [Google Scholar]

84. Makris S, Johansson C. R848 or influenza virus can induce potent innate immune responses in the lungs of neonatal mice. Mucosal Immunol. 2020;10:5–10. [PMC free article] [PubMed] [Google Scholar]

85. Lines JL, Hoskins S, Hollifield M, Cauley LS, Garvy BA. The migration of T cells in response to influenza virus is altered in neonatal mice. J. Immunol. 2010;185:2980–2988. [PMC free article] [PubMed] [Google Scholar]

86. Warnatsch A, et al. Reactive oxygen species localization programs inflammation to clear microbes of different size. Immunity. 2017;46:421–432. [PMC free article] [PubMed] [Google Scholar]

87. Branzk N, et al. Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nat. Immunol. 2014;15:1017–1025. [PMC free article] [PubMed] [Google Scholar]

88. Mócsai A. Diverse novel functions of neutrophils in immunity, inflammation, and beyond. J. Exp. Med. 2013;210:1283–1299. [PMC free article] [PubMed] [Google Scholar]

89. Castanheira FVS, Kubes P. Neutrophils and NETs in modulating acute and chronic inflammation. Blood. 2019;133:2178–2185. [PubMed] [Google Scholar]

90. Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A. Neutrophil function: from mechanisms to disease. Annu. Rev. Immunol. 2012;30:459–489. [PubMed] [Google Scholar]

91. Bardoel BW, Kenny EF, Sollberger G, Zychlinsky A. The balancing act of neutrophils. Cell Host Microbe. 2014;15:526–536. [PubMed] [Google Scholar]

92. Graça-Souza AV, Arruda MAB, de Freitas MS, Barja-Fidalgo C, Oliveira PL. Neutrophil activation by heme: implications for inflammatory processes. Blood. 2002;99:4160–4165. [PubMed] [Google Scholar]

93. Condliffe AM, Kitchen E, Chilvers ER. Neutrophil priming: pathophysiological consequences and underlying mechanisms. Clin. Sci. 1998;94:461–471. [PubMed] [Google Scholar]

94. Buckle AM, Hogg N. The effect of IFN-gamma and colony-stimulating factors on the expression of neutrophil cell membrane receptors. J. Immunol. 1989;143:2295–2301. [PubMed] [Google Scholar]

95. Kato T, Kitagawa S. Regulation of neutrophil functions by proinflammatory cytokines. Int. J. Hematol. 2006;84:205–209. [PubMed] [Google Scholar]

96. Thomas CJ, Schroder K. Pattern recognition receptor function in neutrophils. Trends Immunol. 2013;34:317–328. [PubMed] [Google Scholar]

97. Selvatici R, Falzarano S, Mollica A, Spisani S. Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils. Eur. J. Pharmacol. 2006;534:1–11. [PubMed] [Google Scholar]

98. Suzuki K, et al. Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1β J. Immunol. 2001;167:5940–5947. [PubMed] [Google Scholar]

99. Guthrie LA, McPhail LC, Henson PM, Johnston RJ. Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. J. Exp. Med. 1984;160:1656–1671. [PMC free article] [PubMed] [Google Scholar]

100. El-Benna J, Dang PM-C, Gougerot-Pocidalo M-A. Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Semin. Immunopathol. 2008;30:279–289. [PubMed] [Google Scholar]

101. Colotta F, Re F, Polentarutti N, Sozzani S, Mantovani A. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood. 1992;80:2012–2020. [PubMed] [Google Scholar]

102. Constantini C, et al. Neutrophil activation and survival are modulated by interaction with NK cells. Int. Immunol. 2010;22:827–838. [PubMed] [Google Scholar]

103. Dienz O, et al. Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung. Mucosal Immunol. 2012;5:258–266. [PMC free article] [PubMed] [Google Scholar]

104. Lindemans CA, et al. Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-kappaB-dependent mechanism. J. Immunol. 2006;176:5529–5537. [PubMed] [Google Scholar]

105. Bataki EL, Evans GS, Everard ML. Respiratory syncytial virus and neutrophil activation. Clin. Exp. Immunol. 2005;140:470–477. [PMC free article] [PubMed] [Google Scholar]

106. Cid J, Aguinaco R, Sanchez R, Garcia-Pardo G, Llorente A. Neutrophil CD64 expression as marker of bacterial infection: a systematic review and meta-analysis. J. Infect. 2010;60:313–319. [PubMed] [Google Scholar]

107. Fortunati E, Kazemier KM, Grutters JC, Koenderman L, Van den Bosch VJMM. Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease. Clin. Exp. Immunol. 2009;155:559–566. [PMC free article] [PubMed] [Google Scholar]

108. Hoffmann JJML. Neutrophil CD64: a diagnostic marker for infection and sepsis. Clin. Chem. Lab. Med. 2009;47:671–14. [PubMed] [Google Scholar]

109. Pauksens K, Fjaertoft G, Douhan-Håkansson L, Venge P. Neutrophil and monocyte receptor expression in uncomplicated and complicated influenza A infection with pneumonia. Scand. J. Infect. Dis. 2009;40:326–337. [PubMed] [Google Scholar]

110. Fjaertoft G, Pauksen K, Håkansson L, Xu S, Venge P. Cell surface expression of FcγRI (CD64) on neutrophils and monocytes in patients with influenza A, with and without complications. Scand. J. Infect. Dis. 2009;37:882–889. [PubMed] [Google Scholar]

111. Melendez AJ, Tay HK. Phagocytosis: a repertoire of receptors and Ca2+ as a key second messenger. Biosci. Rep. 2008;28:287–298. [PubMed] [Google Scholar]

112. Wang J. Neutrophils in tissue injury and repair. Cell Tissue Res. 2018;371:1–9. [Google Scholar]

113. Wang Y, Jönsson F. Expression, role, and regulation of neutrophil Fcγ receptors. Front. Immunol. 2019;10:1958. [PMC free article] [PubMed] [Google Scholar]

114. Ng LG, Ostuni R, Hidalgo A. Heterogeneity of neutrophils. Nat. Rev. Immunol. 2019;19:255–265. [PubMed] [Google Scholar]

115. Arnardottir HH, Freysdottir J, Hardardottir I. Two circulating neutrophil populations in acute inflammation in mice. Inflamm. Res. 2012;61:931–939. [PubMed] [Google Scholar]

116. Peñaloza HF, Salazar-Echegarai FJ, Bueno SM. Interleukin 10 modulation of neutrophil subsets infiltrating lungs during Streptococcus pneumoniae infection. Biochem. Biophys. Rep. 2018;13:12–16. [PMC free article] [PubMed] [Google Scholar]

117. Hong C-W. Current understanding in neutrophil differentiation and heterogeneity. Immune Netw. 2017;17:298–299. [PMC free article] [PubMed] [Google Scholar]

118. Carmona-Rivera C, Kaplan MJ. Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity. Semin. Immunopathol. 2013;35:455–463. [PMC free article] [PubMed] [Google Scholar]

119. Rørvig S, Østergaard O, Heegaard NHH, Borregaard N. Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors. J. Leukoc. Biol. 2013;94:711–721. [PubMed] [Google Scholar]

120. Faurschou M, Borregaard N. Neutrophil granules and secretory vesicles in inflammation. Microbes Infect. 2003;5:1317–1327. [PubMed] [Google Scholar]

121. Cowland JB, Borregaard N. Granulopoiesis and granules of human neutrophils. Immunol. Rev. 2016;273:11–28. [PubMed] [Google Scholar]

122. Pham CTN. Neutrophil serine proteases: specific regulators of inflammation. Nat. Rev. Immunol. 2006;6:541–550. [PubMed] [Google Scholar]

123. Keck T, Balcom JH, IV, Castillo CFD, Antoniu BA, Warshaw AL. Matrix metalloproteinase-9 promotes neutrophil migration and alveolar capillary leakage in pancreatitis-associated lung injury in the rat. Gastroenterology. 2002;122:188–201. [PubMed] [Google Scholar]

124. Kruger P, et al. Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS Pathog. 2015;11:e1004651. [PMC free article] [PubMed] [Google Scholar]

125. Dabo AJ, Cummins N, Eden E, Geraghty P. Matrix metalloproteinase 9 exerts antiviral activity against respiratory syncytial virus. PLoS ONE. 2015;10:e0135970–18. [PMC free article] [PubMed] [Google Scholar]

126. Borregaard N. Development of neutrophil granule diversity. Ann. N. Y. Acad. Sci. 2006;15:62–68. [PubMed] [Google Scholar]

127. Emboriadou M, et al. Human neutrophil elastase in RSV bronchiolitis. Ann. Clin. Lab. Sci. 2007;37:79–84. [PubMed] [Google Scholar]

128. Abu-Harb M, et al. IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis. Eur. Respir. J. 1999;14:139–143. [PubMed] [Google Scholar]

129. Sørensen OE, et al. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood. 2001;97:3951–3959. [PubMed] [Google Scholar]

130. Kościuczuk EM, et al. Cathelicidins: family of antimicrobial peptides. A review. Mol. Biol. Rep. 2012;39:10957–10970. [PMC free article] [PubMed] [Google Scholar]

131. Wimley WC, Selsted ME, White SH. Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores. Protein Sci. 2002;3:1362–1373. [PMC free article] [PubMed] [Google Scholar]

132. Tripathi S, et al. The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins. J. Gen. Virol. 2012;94:40–49. [PMC free article] [PubMed] [Google Scholar]

133. Currie SM, et al. Cathelicidins have direct antiviral activity against respiratory syncytial virus in vitro and protective function in vivo in mice and humans. J. Immunol. 2016;196:2699–2710. [PMC free article] [PubMed] [Google Scholar]

134. Currie SM, et al. The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. PLoS ONE. 2013;8:e73659. [PMC free article] [PubMed] [Google Scholar]

135. Tecle T, White MR, Gantz D, Crouch EC, Hartshorn KL. Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses. J. Immunol. 2007;178:8046–8052. [PubMed] [Google Scholar]

136. Doss M, et al. Interactions of α-, β-, and θ-Defensins with influenza A virus and surfactant protein D. J. Immunol. 2009;182:7878–7887. [PubMed] [Google Scholar]

137. Sande CJ, et al. Airway response to respiratory syncytial virus has incidental antibacterial effects. Nat. Commun. 2019;10:1–11. [PMC free article] [PubMed] [Google Scholar]

138. Nguyen GT, Green ER, Mecsas J. Neutrophils to the ROScue: mechanisms of NADPH oxidase activation and bacterial resistance. Front. Cell Infect. Microbiol. 2017;7:339–24. [PMC free article] [PubMed] [Google Scholar]

139. Winterbourn CC, Kettle AJ, Hampton MB. Reactive oxygen species and neutrophil function. Annu. Rev. Biochem. 2016;85:765–792. [PubMed] [Google Scholar]

140. Paiva CN, Bozza MT. Are reactive oxygen species always detrimental to pathogens? Antioxid. Redox Signal. 2014;20:1000–1037. [PMC free article] [PubMed] [Google Scholar]

141. Akiakie T, et al. Pathogenesis of influenza virus‐induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proc. Natl Acad. Sci. USA. 1996;93:2448–2453. [PMC free article] [PubMed] [Google Scholar]

142. Hosakote YM, Liu T, Castro SM, Garofalo RP, Casola A. Respiratory syncytial virus induces oxidative stress by modulating antioxidant enzymes. Am. J. Respir. Cell Mol. Biol. 2009;41:348–357. [PMC free article] [PubMed] [Google Scholar]

143. Mayadas TN, Cullere X, Lowell CA. The multifaceted functions of neutrophils. Annu. Rev. Pathol. 2014;9:181–218. [PMC free article] [PubMed] [Google Scholar]

144. LeVine AM, et al. Surfactant protein-d enhances phagocytosis and pulmonary clearance of respiratory syncytial virus. Am. J. Respir. Cell Mol. Biol. 2004;31:193–199. [PubMed] [Google Scholar]

145. Hartshorn KL, White MR, Tecle T, Holmskov U, Crouch EC. Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D. J. Immunol. 2006;176:6962–6972. [PubMed] [Google Scholar]

146. Hashimoto Y, Moki T, Takizawa T, Shiratsuchi A, Nakanishi Y. Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils and macrophages in mice. J. Immunol. 2007;178:2448–2457. [PubMed] [Google Scholar]

147. Papayannopoulos V. Sweet NETs, bitter wounds. Immunity. 2015;43:223–225. [PubMed] [Google Scholar]

148. Brinkmann V, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–1535. [PubMed] [Google Scholar]

149. Branzk N, Papayannopoulos V. Molecular mechanisms regulating NETosis in infection and disease. Semin. Immunopathol. 2013;35:513–530. [PMC free article] [PubMed] [Google Scholar]

150. Papayannopoulos V. Neutrophil extracellular traps in immunity and disease. Nat. Rev. Immunol. 2018;18:134–147. [PubMed] [Google Scholar]

151. Papayannopoulos V, Metzler KD, Hakkim A, Zychlinsky A. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J. Cell Biol. 2010;191:677–691. [PMC free article] [PubMed] [Google Scholar]

152. Fuchs TA, et al. Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol. 2007;176:231–241. [PMC free article] [PubMed] [Google Scholar]

153. Yipp BG, et al. Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo. Nat. Med. 2019;18:1386–1393. [PMC free article] [PubMed] [Google Scholar]

154. Pilsczek FH, et al. A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus. J. Immunol. 2010;185:7413–7425. [PubMed] [Google Scholar]

155. Wills-Karp M. Neutrophil ghosts worsen asthma. Sci. Immunol. 2018;3:eaau0112. [PubMed] [Google Scholar]

156. Anjani G, et al. Recent advances in chronic granulomatous disease. Genes Dis. 2019;7:84–92. [PMC free article] [PubMed] [Google Scholar]

157. Radermecker C, et al. Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19. J. Exp. Med. 2020;217:120–13. [PMC free article] [PubMed] [Google Scholar]

158. Veras FP, et al. SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology. J. Exp. Med. 2020;217:551–15. [PMC free article] [PubMed] [Google Scholar]

159. Zhu L, et al. High level of neutrophil extracellular traps correlates with poor prognosis of severe influenza A infection. J. Infect. Dis. 2018;217:428–437. [PubMed] [Google Scholar]

160. Narasaraju T, et al. Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis. Am. J. Pathol. 2011;179:199–210. [PMC free article] [PubMed] [Google Scholar]

161. Pillai PS, et al. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science. 2016;352:463–466. [PMC free article] [PubMed] [Google Scholar]

162. Radermecker C, et al. Locally instructed CXCR4hi neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps. Nat. Immunol. 2019;20:1444–1455. [PMC free article] [PubMed] [Google Scholar]

163. Akk A, Springer LE, Pham CTN. Neutrophil extracellular traps enhance early inflammatory response in sendai virus-induced asthma phenotype. Front. Immunol. 2016;7:325. [PMC free article] [PubMed] [Google Scholar]

164. Toussaint M, et al. Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation. Nat. Med. 2017;23:681–691. [PMC free article] [PubMed] [Google Scholar]

165. Hoeksema M, et al. Arginine-rich histones have strong antiviral activity for influenza A viruses. Innate Immun. 2015;21:736–745. [PMC free article] [PubMed] [Google Scholar]

166. Hemmers S, Teijaro JR, Arandjelovic S, Mowen KA. PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection. PLoS ONE. 2011;6:e22043–10. [PMC free article] [PubMed] [Google Scholar]

167. Rojas-Quintero J, et al. Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection. JCI Insight. 2018;3:593–21. [PMC free article] [PubMed] [Google Scholar]

168. Ashar HK, et al. The role of extracellular histones in influenza virus pathogenesis. Am. J. Pathol. 2018;188:135–148. [PMC free article] [PubMed] [Google Scholar]

169. Funchal GA, et al. Respiratory syncytial virus fusion protein promotes TLR-4-dependent neutrophil extracellular trap formation by human neutrophils. PLoS ONE. 2015;10:e0124082. [PMC free article] [PubMed] [Google Scholar]

170. Geerdink RJ, et al. LAIR-1 limits neutrophil extracellular trap formation in viral bronchiolitis. J. Allergy Clin. Immunol. 2017;141:811–814. [PubMed] [Google Scholar]

171. Muraro SXFP, et al. Respiratory syncytial virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation. Sci. Rep. 2018;8:14166. [PMC free article] [PubMed] [Google Scholar]

172. Porto BN, Stein RT. Neutrophil extracellular traps in pulmonary diseases: too much of a good thing? Front. Immunol. 2016;7:173–13. [PMC free article] [PubMed] [Google Scholar]

173. Cassatella MA, Östberg NK, Tamassia N, Soehnlein O. Biological roles of neutrophil-derived granule proteins and cytokines. Trends Immunol. 2019;40:648–664. [PubMed] [Google Scholar]

174. Giacalone VD, Margaroli C, Mall MA, Tirouvanziam R. Neutrophil adaptations upon recruitment to the lung: new concepts and implications for homeostasis and disease. Int J. Mol. Sci. 2020;21:851–21. [PMC free article] [PubMed] [Google Scholar]

175. Brandes M, Klauschen F, Kuchen S, Germain RN. A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection. Cell. 2013;154:197–212. [PMC free article] [PubMed] [Google Scholar]

176. Kirsebom F, Michalaki C, Agueda-Oyarzabal M, Johansson C. Neutrophils do not impact viral load or the peak of disease severity during RSV infection. Sci. Rep. 2020;24:1110. [PMC free article] [PubMed] [Google Scholar]

177. Stokes KL, et al. The respiratory syncytial virus fusion protein and neutrophils mediate the airway mucin response to pathogenic respiratory syncytial virus infection. J. Virol. 2013;87:10070–10082. [PMC free article] [PubMed] [Google Scholar]

178. Halfhide CP, et al. Respiratory syncytial virus binds and undergoes transcription in neutrophils from the blood and airways of infants with severe bronchiolitis. J. Infect. Dis. 2011;204:451–458. [PMC free article] [PubMed] [Google Scholar]

179. Minns D, Smith KJ, Findlay EG. Orchestration of adaptive T cell responses by neutrophil granule contents. Mediators Inflamm. 2019;2019:1–15. [PMC free article] [PubMed] [Google Scholar]

180. Leliefeld PHC, Koenderman L, Pillay J. How neutrophils shape adaptive immune responses. Front. Immunol. 2015;6:471. [PMC free article] [PubMed] [Google Scholar]

181. Schuster S, Hurrell B, Tacchini-Cottier F. Crosstalk between neutrophils and dendritic cells: a context-dependent process. J. Leukoc. Biol. 2013;94:671–675. [PubMed] [Google Scholar]

182. van Gisbergen KPJM, Sanchez-Hernandez M, Geijtenbeek TBH, van Kooyk Y. Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN. J. Exp. Med. 2005;201:1281–1292. [PMC free article] [PubMed] [Google Scholar]

183. Bennouna S, Denkers EY. Microbial antigen triggers rapid mobilization of TNF-alpha to the surface of mouse neutrophils transforming them into inducers of high-level dendritic cell TNF-alpha production. J. Immunol. 2005;174:4845–4851. [PubMed] [Google Scholar]

184. Charmoy M, et al. Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of leishmania major inoculation in resistant mice. PLoS Pathog. 2010;6:e1000755–12. [PMC free article] [PubMed] [Google Scholar]

185. Potter NS, Harding CV. Neutrophils process exogenous bacteria via an alternate class I MHC processing pathway for presentation of peptides to T lymphocytes. J. Immunol. 2001;167:2538–2546. [PubMed] [Google Scholar]

186. Culshaw S, Millington OR, Brewer JM, McInnes IB. Murine neutrophils present class II restricted antigen. Immunol. Lett. 2008;118:49–54. [PMC free article] [PubMed] [Google Scholar]

187. Hufford MM, et al. Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8+ T cells. PLoS ONE. 2012;7:e46581-10. [PMC free article] [PubMed] [Google Scholar]

188. Lim K, et al. In situ neutrophil efferocytosis shapes T cell immunity to influenza infection. Nat. Immunol. 2020;21:1046–1057. [PMC free article] [PubMed] [Google Scholar]

189. Lim K, et al. Neutrophil trails guide influenza-specific CD8+ T cells in the airways. Science. 2015;349:aaa4352. [PMC free article] [PubMed] [Google Scholar]

190. Tate MD, Brooks AG, Reading PC, Mintern JD. Neutrophils sustain effective CD8(+) T-cell responses in the respiratory tract following influenza infection. Immunol. Cell Biol. 2012;90:197–205. [PubMed] [Google Scholar]

191. Tak T, et al. Neutrophil-mediated suppression of influenza-induced pathology requires CD11b/CD18 (MAC-1) Am. J. Respir. Cell Mol. Biol. 2018;58:492–499. [PubMed] [Google Scholar]

192. Reilly EC, Lambert-Emo K, Topham DJ. The effects of acute neutrophil depletion on resolution of acute influenza infection, establishment of tissue resident memory (TRM), and heterosubtypic immunity. PLoS ONE. 2016;11:e0164247. [PMC free article] [PubMed] [Google Scholar]

193. Cerutti A, Puga I, Magri G. The B cell helper side of neutrophils. J. Leukoc. Biol. 2013;94:677–682. [PMC free article] [PubMed] [Google Scholar]

194. Costa S, Bevilacqua D, Cassatella MA, Scapini P. Recent advances on the crosstalk between neutrophils and B or T lymphocytes. Immunology. 2018;156:23–32. [PMC free article] [PubMed] [Google Scholar]

195. Puga I, et al. B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen. Nat. Immunol. 2012;13:170–180. [PMC free article] [PubMed] [Google Scholar]

196. Ratcliffe DR, Michl J, Cramer EB. Neutrophils do not bind to or phagocytize human immune complexes formed with influenza virus. Blood. 1993;82:1639–1646. [PubMed] [Google Scholar]

197. Fujisawa H. Neutrophils play an essential role in cooperation with antibody in both protection against and recovery from pulmonary infection with influenza virus in mice. J. Virol. 2008;82:2772–2783. [PMC free article] [PubMed] [Google Scholar]

198. Stokes KL, et al. Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice. J. Virol. 2011;85:5782–5793. [PMC free article] [PubMed] [Google Scholar]

199. Taylor G. Animal models of respiratory syncytial virus infection. Vaccine. 2017;35:469–480. [PMC free article] [PubMed] [Google Scholar]

200. Makris S, Paulsen M, Johansson C, Type I. Interferons as regulators of lung inflammation. Front. Immunol. 2017;8:259. [PMC free article] [PubMed] [Google Scholar]

201. Jasper AE, McIver WJ, Sapey E, Walton GM. Understanding the role of neutrophils in chronic inflammatory airway disease. F1000Res. 2019;8:557–17. [PMC free article] [PubMed] [Google Scholar]

202. Gehrig S, et al. Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease. Am. J. Respir. Crit. Care Med. 2014;189:1082–1092. [PubMed] [Google Scholar]

203. Ascough S, Paterson S, Chiu C. Induction and subversion of human protective immunity: contrasting influenza and respiratory syncytial virus. Front. Immunol. 2018;9:117. [PMC free article] [PubMed] [Google Scholar]

204. Sun S-H, et al. A mouse model of SARS-CoV-2 infection and pathogenesis. Cell Host Microbe. 2020;28:124–133.e4. [PMC free article] [PubMed] [Google Scholar]

205. Jones HR, Robb CT, Perretti M, Rossi AG. The role of neutrophils in inflammation resolution. Semin. Immunol. 2016;28:137–145. [PubMed] [Google Scholar]

206. Peiseler M, Kubes P. More friend than foe: the emerging role of neutrophils in tissue repair. J. Clin. Investig. 2019;129:2629–2639. [PMC free article] [PubMed] [Google Scholar]

207. Marwick JA, et al. Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-kB activation. Cell Death Dis. 2018;9:1–13. [PMC free article] [PubMed] [Google Scholar]

208. Deng Y, et al. Neutrophil-airway epithelial interactions result in increased epithelial damage and viral clearance during respiratory syncytial virus infection. J. Virol. 2020;94:946. [PMC free article] [PubMed] [Google Scholar]

209. Campbell EL, et al. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014;40:66–77. [PMC free article] [PubMed] [Google Scholar]

210. Hoenderdos K, et al. Hypoxia upregulates neutrophil degranulation and potential for tissue injury. Thorax. 2016;71:1030–1038. [PMC free article] [PubMed] [Google Scholar]

211. Thorburn K, Harigopal S, Reddy V, Taylor N, van Saene HKF. High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis. Thorax. 2006;61:611–615. [PMC free article] [PubMed] [Google Scholar]

212. Hall CB, Powell KR, Schnabel KC, Gala CL, Pincus PH. Risk of secondary bacterial infection in infants hospitalized with respiratory syncytial viral infection. J. Pediatr. 1988;113:266–271. [PubMed] [Google Scholar]

213. Hendaus M, Jomha F, Alhammadi A. Virus-induced secondary bacterial infection: a concise review. Thera. Clin. Risk Manag. 2015;11:1265–1271. [PMC free article] [PubMed] [Google Scholar]

214. Morens DM, Taubenberger JK, Fauci AS. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J. Infect. Dis. 2008;198:962–970. [PMC free article] [PubMed] [Google Scholar]

215. McNamee LA, Harmsen AG. Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection. Infect. Immun. 2006;74:6707–6721. [PMC free article] [PubMed] [Google Scholar]

216. Ellis GT, et al. TRAIL + monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza—Streptococcus pneumoniae coinfection. EMBO Rep. 2015;16:1203–1218. [PMC free article] [PubMed] [Google Scholar]

217. Shahangian A, et al. Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. JCI. 2009;119:1910–1920. [PMC free article] [PubMed] [Google Scholar]

218. Kukavica-Ibrulj I, et al. Infection with human metapneumovirus predisposes mice to severe pneumococcal pneumonia. J. Virol. 2009;83:1341–1349. [PMC free article] [PubMed] [Google Scholar]

219. Engelich G, White M, Hartshorn KL. Neutrophil survival is markedly reduced by incubation with influenza virus and Streptococcus pneumoniae: role of respiratory burst. J. Leukoc. Biol. 2001;69:50–56. [PubMed] [Google Scholar]

220. Ishikawa H, et al. Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung. Virology. 2016;499:23–29. [PubMed] [Google Scholar]

221. Villeret B, et al. Influenza a virus pre-infection exacerbates Pseudomonas aeruginosa-mediated lung damage through increased MMP-9 expression, decreased elafin production and tissue resilience. Front. Immunol. 2020;11:117. [PMC free article] [PubMed] [Google Scholar]

222. Grunwell JR, et al. Neutrophil dysfunction in the airways of children with acute respiratory failure due to lower respiratory tract viral and bacterial coinfections. Sci. Rep. 2019;9:1–13. [PMC free article] [PubMed] [Google Scholar]

223. Cortjens B, et al. Neutrophil subset responses in infants with severe viral respiratory infection. Clin. Immunol. 2017;176:100–106. [PubMed] [Google Scholar]

224. Schmid MA, et al. Influenza and dengue virus co-infection impairs monocyte recruitment to the lung, increases dengue virus titers, and exacerbates pneumonia. Eur. J. Immunol. 2017;47:527–539. [PubMed] [Google Scholar]

225. Tobin JM, et al. Influenza suppresses neutrophil recruitment to the lung and exacerbates secondary invasive pulmonary aspergillosis. J. Immunol. 2020;205:480–488. [PMC free article] [PubMed] [Google Scholar]

226. Habibi MS, et al. Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection. Science. 2020;370:eaba9301. [PMC free article] [PubMed] [Google Scholar]

227. J Jackson D, Johnston SL. The role of viruses in acute exacerbations of asthma. JACI. 2010;125:1178–1187. [PMC free article] [PubMed] [Google Scholar]

228. Busse WW, Lemanske RF, Gern JE. Role of viral respiratory infections in asthma and asthma exacerbations. Lancet. 2010;376:826–834. [PMC free article] [PubMed] [Google Scholar]

229. Ray A, Kolls JK. Neutrophilic inflammation in asthma and association with disease severity. Trends Immunol. 2017;38:942–954. [PMC free article] [PubMed] [Google Scholar]

230. Jartti T, Gern JE. Role of viral infections in the development and exacerbation of asthma in children. JACI. 2017;140:895–906. [PMC free article] [PubMed] [Google Scholar]

231. Graff Stensballe L, et al. The causal direction in the association between respiratory syncytial virus hospitalization and asthma. JACI. 2009;123:131–137. [PubMed] [Google Scholar]

232. Krishnamoorthy N, et al. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci. Immunol. 2018;3:eaao4747. [PMC free article] [PubMed] [Google Scholar]

233. Tang FSM, et al. Differential neutrophil activation in viral infections: enhanced TLR-7/8-mediated CXCL8 release in asthma. Respirology. 2015;21:172–179. [PMC free article] [PubMed] [Google Scholar]

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Multiple ways to activate a neutrophil.

Neutrophils receive many different signals from the inflammatory environment that can lead to cell activation and elicit effector functions. These activating signals include PAMPs, DAMPs, the process of migration, neutrophil chemoattractants, and cytokines.

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