A patient admitted with diabetic ketoacidosis was treated for metabolic acidosis

  1. Kimmoun A, Novy E, Auchet T, Ducrocq N, Levy B. Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside. Crit Care Lond Engl. 2015;19:175.

    Article  Google Scholar 

  2. Kraut JA, Madias NE. Treatment of acute metabolic acidosis: a pathophysiologic approach. Nat Rev Nephrol. 2012;8(10):589–601.

    Article  CAS  PubMed  Google Scholar 

  3. Kraut JA, Madias NE. Metabolic acidosis: pathophysiology, diagnosis and management. Nat Rev Nephrol. 2010;6(5):274–85.

    Article  CAS  PubMed  Google Scholar 

  4. Asch MJ, Dell RB, Williams GS, Cohen M, Winters RW. Time course for development of respiratory compensation in metabolic acidosis. J Lab Clin Med. 1969;73(4):610–5.

    CAS  PubMed  Google Scholar 

  5. Fulop M. A guide for predicting arterial CO2 tension in metabolic acidosis. Am J Nephrol. 1997;17(5):421–4.

    Article  CAS  PubMed  Google Scholar 

  6. Batlle D, Chin-Theodorou J, Tucker BM. Metabolic acidosis or respiratory alkalosis? evaluation of a low plasma bicarbonate using the urine anion gap. Am J Kidney Dis Off J Natl Kidney Found. 2017;70(3):440–4.

    Article  CAS  Google Scholar 

  7. Bloom BM, Grundlingh J, Bestwick JP, Harris T. The role of venous blood gas in the emergency department: a systematic review and meta-analysis. Eur J Emerg Med Off J Eur Soc Emerg Med. 2014;21(2):81–8.

    Article  Google Scholar 

  8. Ma OJ, Rush MD, Godfrey MM, Gaddis G. Arterial blood gas results rarely influence emergency physician management of patients with suspected diabetic ketoacidosis. Acad Emerg Med Off J Soc Acad Emerg Med. 2003;10(8):836–41.

    Article  Google Scholar 

  9. Arnold TDW, Miller M, van Wessem KP, Evans JA, Balogh ZJ. Base deficit from the first peripheral venous sample: a surrogate for arterial base deficit in the trauma bay. J Trauma. 2011;71(4):793–7 (discussion 797).

    Article  PubMed  Google Scholar 

  10. Zakrison T, McFarlan A, Wu YY, Keshet I, Nathens A. Venous and arterial base deficits: do these agree in occult shock and in the elderly? A Bland-Altman analysis. J Trauma Acute Care Surg. 2013;74(3):936–9.

    Article  PubMed  Google Scholar 

  11. Herrington WG, Nye HJ, Hammersley MS, Watkinson PJ. Are arterial and venous samples clinically equivalent for the estimation of pH, serum bicarbonate and potassium concentration in critically ill patients? Diabet Med J Br Diabet Assoc. 2012;29(1):32–5.

    Article  CAS  Google Scholar 

  12. Surbatovic M, Radakovic S, Jevtic M, Filipovic N, Romic P, Popovic N, et al. Predictive value of serum bicarbonate, arterial base deficit/excess and SAPS III score in critically ill patients. Gen Physiol Biophys. 2009;28:271–6.

    PubMed  Google Scholar 

  13. Martin MJ, FitzSullivan E, Salim A, Berne TV, Towfigh S. Use of serum bicarbonate measurement in place of arterial base deficit in the surgical intensive care unit. Arch Surg Chic Ill 1960. 2005;140(8):745–51.

    Google Scholar 

  14. FitzSullivan E, Salim A, Demetriades D, Asensio J, Martin MJ. Serum bicarbonate may replace the arterial base deficit in the trauma intensive care unit. Am J Surg. 2005;190(6):941–6.

    Article  PubMed  Google Scholar 

  15. Chawla LS, Jagasia D, Abell LM, Seneff MG, Egan M, Danino N, et al. Anion gap, anion gap corrected for albumin, and base deficit fail to accurately diagnose clinically significant hyperlactatemia in critically ill patients. J Intensive Care Med. 2008;23(2):122–7.

    Article  PubMed  Google Scholar 

  16. Dinh CH, Ng R, Grandinetti A, Joffe A, Chow DC. Correcting the anion gap for hypoalbuminaemia does not improve detection of hyperlactataemia. Emerg Med J EMJ. 2006;23(8):627–9.

    Article  CAS  PubMed  Google Scholar 

  17. Moviat M, van Haren F, van der Hoeven H. Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis. Crit Care Lond Engl. 2003;7(3):R41–5.

    Article  Google Scholar 

  18. Mallat J, Michel D, Salaun P, Thevenin D, Tronchon L. Defining metabolic acidosis in patients with septic shock using Stewart approach. Am J Emerg Med. 2012;30(3):391–8.

    Article  PubMed  Google Scholar 

  19. Chawla LS, Shih S, Davison D, Junker C, Seneff MG. Anion gap, anion gap corrected for albumin, base deficit and unmeasured anions in critically ill patients: implications on the assessment of metabolic acidosis and the diagnosis of hyperlactatemia. BMC Emerg Med. 2008;8:18.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  20. Dubin A, Menises MM, Masevicius FD, Moseinco MC, Kutscherauer DO, Ventrice E, et al. Comparison of three different methods of evaluation of metabolic acid–base disorders. Crit Care Med. 2007;35(5):1264–70.

    Article  CAS  PubMed  Google Scholar 

  21. Story DA, Poustie S, Bellomo R. Estimating unmeasured anions in critically ill patients: anion-gap, base-deficit, and strong-ion-gap. Anaesthesia. 2002;57(11):1109–14.

    Article  CAS  PubMed  Google Scholar 

  22. Balasubramanyan N, Havens PL, Hoffman GM. Unmeasured anions identified by the Fencl–Stewart method predict mortality better than base excess, anion gap, and lactate in patients in the pediatric intensive care unit. Crit Care Med. 1999;27(8):1577–81.

    Article  CAS  PubMed  Google Scholar 

  23. Lautrette A, Fejjal M, Aithssain A, Phan TN, Caillot N, Fogli A, et al. Comparison of three methods of diagnosis of plasma unmeasured anions in critically ill patients. Minerva Anestesiol. 2013;79(10):1164–72.

    CAS  PubMed  Google Scholar 

  24. Boniatti MM, Cardoso PRC, Castilho RK, Vieira SRR. Acid–base disorders evaluation in critically ill patients: we can improve our diagnostic ability. Intensive Care Med. 2009;35(8):1377–82.

    Article  PubMed  Google Scholar 

  25. Nanji AA, Campbell DJ, Pudek MR. Decreased anion gap associated with hypoalbuminemia and polyclonal gammopathy. JAMA. 1981;246(8):859–60.

    Article  CAS  PubMed  Google Scholar 

  26. Figge J, Jabor A, Kazda A, Fencl V. Anion gap and hypoalbuminemia. Crit Care Med. 1998;26(11):1807–10.

    Article  CAS  PubMed  Google Scholar 

  27. Fencl V, Jabor A, Kazda A, Figge J. Diagnosis of metabolic acid–base disturbances in critically ill patients. Am J Respir Crit Care Med. 2000;162(6):2246–51.

    Article  CAS  PubMed  Google Scholar 

  28. Kraut JA, Madias NE. Differential diagnosis of nongap metabolic acidosis: value of a systematic approach. Clin J Am Soc Nephrol CJASN. 2012;7(4):671–9.

    Article  PubMed  Google Scholar 

  29. Adrogué HJ, Madias NE. Assessing acid–base status: physiologic versus physicochemical approach. Am J Kidney Dis Off J Natl Kidney Found. 2016;68(5):793–802.

    Article  CAS  Google Scholar 

  30. Tuhay G, Pein MC, Masevicius FD, Kutscherauer DO, Dubin A. Severe hyperlactatemia with normal base excess: a quantitative analysis using conventional and Stewart approaches. Crit Care Lond Engl. 2008;12(3):R66.

    Article  Google Scholar 

  31. Guérin C, Nesme P, Leray V, Wallet F, Bourdin G, Bayle F, et al. Quantitative analysis of acid–base disorders in patients with chronic respiratory failure in stable or unstable respiratory condition. Respir Care. 2010;55(11):1453–63.

    PubMed  Google Scholar 

  32. Magder S, Emami A. Practical approach to physical–chemical acid–base management Stewart at the bedside. Ann Am Thorac Soc. 2015;12(1):111–7.

    Article  PubMed  Google Scholar 

  33. Galbois A, Ait-Oufella H, Baudel J-L, Maury E, Offenstadt G. An adult can still die of salicylate poisoning in France in 2008. Intensive Care Med. 2009;35(11):1999.

    Article  PubMed  Google Scholar 

  34. Pernet P, Bénéteau-Burnat B, Vaubourdolle M, Maury E, Offenstadt G. False elevation of blood lactate reveals ethylene glycol poisoning. Am J Emerg Med. 2009;27(1):132.e1–2.

    Article  Google Scholar 

  35. Adrogué HJ, Wilson H, Boyd AE, Suki WN, Eknoyan G. Plasma acid–base patterns in diabetic ketoacidosis. N Engl J Med. 1982;307(26):1603–10.

    Article  PubMed  Google Scholar 

  36. Richardson RM, Halperin ML. The urine pH: a potentially misleading diagnostic test in patients with hyperchloremic metabolic acidosis. Am J Kidney Dis Off J Natl Kidney Found. 1987;10(2):140–3.

    Article  CAS  Google Scholar 

  37. Kraut JA, Mullins ME. Toxic alcohols. N Engl J Med. 2018;378(3):270–80.

    Article  CAS  PubMed  Google Scholar 

  38. Noritomi DT, Soriano FG, Kellum JA, Cappi SB, Biselli PJC, Libório AB, et al. Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study. Crit Care Med. 2009;37(10):2733–9.

    Article  CAS  PubMed  Google Scholar 

  39. Rastegar M, Nagami GT. Non-anion gap metabolic acidosis: a clinical approach to evaluation. Am J Kidney Dis Off J Natl Kidney Found. 2017;69(2):296–301.

    Article  CAS  Google Scholar 

  40. Kim HY, Han JS, Jeon US, Joo KW, Earm JH, Ahn C, et al. Clinical significance of the fractional excretion of anions in metabolic acidosis. Clin Nephrol. 2001;55(6):448–52.

    CAS  PubMed  Google Scholar 

  41. Batlle DC, Hizon M, Cohen E, Gutterman C, Gupta R. The use of the urinary anion gap in the diagnosis of hyperchloremic metabolic acidosis. N Engl J Med. 1988;318(10):594–9.

    Article  CAS  PubMed  Google Scholar 

  42. Brunner R, Drolz A, Scherzer T-M, Staufer K, Fuhrmann V, Zauner C, et al. Renal tubular acidosis is highly prevalent in critically ill patients. Crit Care Lond Engl. 2015;19:148.

    Article  Google Scholar 

  43. Guyette FX, Meier EN, Newgard C, McKnight B, Daya M, Bulger EM, et al. A comparison of prehospital lactate and systolic blood pressure for predicting the need for resuscitative care in trauma transported by ground. J Trauma Acute Care Surg. 2015;78(3):600–6.

    Article  CAS  PubMed  Google Scholar 

  44. Contenti J, Corraze H, Lemoël F, Levraut J. Effectiveness of arterial, venous, and capillary blood lactate as a sepsis triage tool in ED patients. Am J Emerg Med. 2015;33(2):167–72.

    Article  PubMed  Google Scholar 

  45. Musikatavorn K, Thepnimitra S, Komindr A, Puttaphaisan P, Rojanasarntikul D. Venous lactate in predicting the need for intensive care unit and mortality among nonelderly sepsis patients with stable hemodynamic. Am J Emerg Med. 2015;33(7):925–30.

    Article  PubMed  Google Scholar 

  46. Barfod C, Lundstrøm LH, Lauritzen MMP, Danker JK, Sölétormos G, Forberg JL, et al. Peripheral venous lactate at admission is associated with in-hospital mortality, a prospective cohort study. Acta Anaesthesiol Scand. 2015;59(4):514–23.

    Article  CAS  PubMed  Google Scholar 

  47. Bouzat P, Schilte C, Vinclair M, Manhes P, Brun J, Bosson J-L, et al. Capillary lactate concentration on admission of normotensive trauma patients: a prospective study. Scand J Trauma Resusc Emerg Med. 2016;24:82.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Gaieski DF, Drumheller BC, Goyal M, Fuchs BD, Shofer FS, Zogby K. Accuracy of handheld point-of-care fingertip lactate measurement in the emergency department. West J Emerg Med. 2013;14(1):58–62.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Kim C, Kim H. Emergency medical technician-performed point-of-care blood analysis using the capillary blood obtained from skin puncture. Am J Emerg Med. 2018;36(7):1215–21.

    Article  PubMed  Google Scholar 

  50. Collange O, Garcia V, Kindo M, Meyer N, Lavaux T, Mertes PM, et al. Comparison of capillary and arterial lactate levels in patients with shock. Anaesth Crit Care Pain Med. 2017;36(3):157–62.

    Article  PubMed  Google Scholar 

  51. Seoane L, Papasidero M, De Sanctis P, Posadas-Martínez LM, Soler S, Rodríguez M. Capillary lactic acid validation in an ED. Am J Emerg Med. 2013;31(9):1365–7.

    Article  PubMed  Google Scholar 

  52. Tanner RK, Fuller KL, Ross MLR. Evaluation of three portable blood lactate analysers: lactate pro, lactate scout and lactate plus. Eur J Appl Physiol. 2010;109(3):551–9.

    Article  CAS  PubMed  Google Scholar 

  53. Manzon C, Barrot L, Besch G, Barbot O, Desmettre T, Capellier G, et al. Capillary lactate as a tool for the triage nurse among patients with SIRS at emergency department presentation: a preliminary report. Ann Intensive Care. 2015;5:7.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Kraut JA, Madias NE. Lactic acidosis. N Engl J Med. 2014;371(24):2309–19.

    Article  PubMed  CAS  Google Scholar 

  55. Vernon C, Letourneau JL. Lactic acidosis: recognition, kinetics, and associated prognosis. Crit Care Clin. 2010;26(2):255–83.

    Article  CAS  PubMed  Google Scholar 

  56. Blohm E, Lai J, Neavyn M. Drug-induced hyperlactatemia. Clin Toxicol Phila Pa. 2017;55(8):869–78.

    Article  Google Scholar 

  57. Suetrong B, Walley KR. Lactic acidosis in sepsis: it’s not all anaerobic: implications for diagnosis and management. Chest. 2016;149(1):252–61.

    Article  PubMed  Google Scholar 

  58. Laffel LMB, Wentzell K, Loughlin C, Tovar A, Moltz K, Brink S. Sick day management using blood 3-hydroxybutyrate (3-OHB) compared with urine ketone monitoring reduces hospital visits in young people with T1DM: a randomized clinical trial. Diabet Med J Br Diabet Assoc. 2006;23(3):278–84.

    Article  CAS  Google Scholar 

  59. Taboulet P, Deconinck N, Thurel A, Haas L, Manamani J, Porcher R, et al. Correlation between urine ketones (acetoacetate) and capillary blood ketones (3-beta-hydroxybutyrate) in hyperglycaemic patients. Diabetes Metab. 2007;33(2):135–9.

    Article  CAS  PubMed  Google Scholar 

  60. Voulgari C, Tentolouris N. The performance of a glucose-ketone meter in the diagnosis of diabetic ketoacidosis in patients with type 2 diabetes in the emergency room. Diabetes Technol Ther. 2010;12(7):529–35.

    Article  CAS  PubMed  Google Scholar 

  61. Arora S, Henderson SO, Long T, Menchine M. Diagnostic accuracy of point-of-care testing for diabetic ketoacidosis at emergency-department triage: {beta}-hydroxybutyrate versus the urine dipstick. Diabetes Care. 2011;34(4):852–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Charles RA, Bee YM, Eng PHK, Goh SY. Point-of-care blood ketone testing: screening for diabetic ketoacidosis at the emergency department. Singapore Med J. 2007;48(11):986–9.

    CAS  PubMed  Google Scholar 

  63. Kuru B, Sever M, Aksay E, Dogan T, Yalcin N, Eren ES, et al. Comparing finger-stick β-hydroxybutyrate with dipstick urine tests in the detection of ketone bodies. Turk J Emerg Med. 2014;14(2):47–52.

    Article  PubMed  Google Scholar 

  64. Shin J, Lim YS, Kim K, Lee HJ, Lee SJ, Jung E, et al. Initial blood pH during cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients: a multicenter observational registry-based study. Crit Care Lond Engl. 2017;21(1):322.

    Article  Google Scholar 

  65. Spindelboeck W, Gemes G, Strasser C, Toescher K, Kores B, Metnitz P, et al. Arterial blood gases during and their dynamic changes after cardiopulmonary resuscitation: a prospective clinical study. Resuscitation. 2016;106:24–9.

    Article  PubMed  Google Scholar 

  66. Denton R, Thomas AN. Cardiopulmonary resuscitation: a retrospective review. Anaesthesia. 1997;52(4):324–7.

    Article  CAS  PubMed  Google Scholar 

  67. Kaplan LJ, Kellum JA. Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. Crit Care Med. 2004;32(5):1120–4.

    Article  CAS  PubMed  Google Scholar 

  68. Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997;336(4):243–50.

    Article  CAS  PubMed  Google Scholar 

  69. Renaud B, Labarère J, Coma E, Santin A, Hayon J, Gurgui M, et al. Risk stratification of early admission to the intensive care unit of patients with no major criteria of severe community-acquired pneumonia: development of an international prediction rule. Crit Care Lond Engl. 2009;13(2):R54.

    Article  Google Scholar 

  70. Shapiro NI, Howell MD, Talmor D, Nathanson LA, Lisbon A, Wolfe RE, et al. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med. 2005;45(5):524–8.

    Article  PubMed  Google Scholar 

  71. Casserly B, Phillips GS, Schorr C, Dellinger RP, Townsend SR, Osborn TM, et al. Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med. 2015;43(3):567–73.

    Article  CAS  PubMed  Google Scholar 

  72. Park YJ, Kim DH, Kim SC, Kim TY, Kang C, Lee SH, et al. Serum lactate upon emergency department arrival as a predictor of 30-day in-hospital mortality in an unselected population. PLoS ONE. 2018;13(1):e0190519.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  73. Puskarich MA, Kline JA, Summers RL, Jones AE. Prognostic value of incremental lactate elevations in emergency department patients with suspected infection. Acad Emerg Med Off J Soc Acad Emerg Med. 2012;19(8):983–5.

    Article  Google Scholar 

  74. Raux M, Le Manach Y, Gauss T, Baumgarten R, Hamada S, Harrois A, et al. Comparison of the prognostic significance of initial blood lactate and base deficit in trauma patients. Anesthesiology. 2017;126(3):522–33.

    Article  CAS  PubMed  Google Scholar 

  75. Régnier M-A, Raux M, Le Manach Y, Asencio Y, Gaillard J, Devilliers C, et al. Prognostic significance of blood lactate and lactate clearance in trauma patients. Anesthesiology. 2012;117(6):1276–88.

    Article  PubMed  CAS  Google Scholar 

  76. Ryoo SM, Lee J, Lee Y-S, Lee JH, Lim KS, Huh JW, et al. Lactate level versus lactate clearance for predicting mortality in patients with septic shock defined by sepsis-3. Crit Care Med. 2018;46(6):e489–95.

    Article  CAS  PubMed  Google Scholar 

  77. Dezman ZDW, Comer AC, Smith GS, Narayan M, Scalea TM, Hirshon JM. Failure to clear elevated lactate predicts 24-hour mortality in trauma patients. J Trauma Acute Care Surg. 2015;79(4):580–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. May ME, Young C, King J. Resource utilization in treatment of diabetic ketoacidosis in adults. Am J Med Sci. 1993;306(5):287–94.

    Article  CAS  PubMed  Google Scholar 

  79. Moss JM. Diabetic ketoacidosis: effective low-cost treatment in a community hospital. South Med J. 1987;80(7):875–81.

    Article  CAS  PubMed  Google Scholar 

  80. Marinac JS, Mesa L. Using a severity of illness scoring system to assess intensive care unit admissions for diabetic ketoacidosis. Crit Care Med. 2000;28(7):2238–41.

    Article  CAS  PubMed  Google Scholar 

  81. Gershengorn HB, Iwashyna TJ, Cooke CR, Scales DC, Kahn JM, Wunsch H. Variation in use of intensive care for adults with diabetic ketoacidosis. Crit Care Med. 2012;40(7):2009–15.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Andrade-Castellanos CA, Colunga-Lozano LE, Delgado-Figueroa N, Gonzalez-Padilla DA. Subcutaneous rapid-acting insulin analogues for diabetic ketoacidosis. Cochrane Database Syst Rev. 2016;1:CD011281.

    Google Scholar 

  83. Vincent M, Nobécourt E. Treatment of diabetic ketoacidosis with subcutaneous insulin lispro: a review of the current evidence from clinical studies. Diabetes Metab. 2013;39(4):299–305.

    Article  CAS  PubMed  Google Scholar 

  84. Fisher JN, Shahshahani MN, Kitabchi AE. Diabetic ketoacidosis: low-dose insulin therapy by various routes. N Engl J Med. 1977;297(5):238–41.

    Article  CAS  PubMed  Google Scholar 

  85. Umpierrez GE, Latif K, Stoever J, Cuervo R, Park L, Freire AX, et al. Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis. Am J Med. 2004;117(5):291–6.

    Article  CAS  PubMed  Google Scholar 

  86. Umpierrez GE, Cuervo R, Karabell A, Latif K, Freire AX, Kitabchi AE. Treatment of diabetic ketoacidosis with subcutaneous insulin aspart. Diabetes Care. 2004;27(8):1873–8.

    Article  CAS  PubMed  Google Scholar 

  87. Karoli R, Fatima J, Salman T, Sandhu S, Shankar R. Managing diabetic ketoacidosis in non-intensive care unit setting: role of insulin analogs. Indian J Pharmacol. 2011;43(4):398–401.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Kitabchi AE, Murphy MB, Spencer J, Matteri R, Karas J. Is a priming dose of insulin necessary in a low-dose insulin protocol for the treatment of diabetic ketoacidosis? Diabetes Care. 2008;31(11):2081–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Goyal N, Miller JB, Sankey SS, Mossallam U. Utility of initial bolus insulin in the treatment of diabetic ketoacidosis. J Emerg Med. 2010;38(4):422–7.

    Article  PubMed  Google Scholar 

  90. Page MM, Alberti KG, Greenwood R, Gumaa KA, Hockaday TD, Lowy C, et al. Treatment of diabetic coma with continuous low-dose infusion of insulin. Br Med J. 1974;2(5921):687–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Semple PF, White C, Manderson WG. Continuous intravenous infusion of small doses of insulin in treatment of diabetic ketoacidosis. Br Med J. 1974;2(5921):694–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. El-Solh AA, Abou Jaoude P, Porhomayon J. Bicarbonate therapy in the treatment of septic shock: a second look. Intern Emerg Med. 2010;5(4):341–7.

    Article  PubMed  Google Scholar 

  93. Kim HJ, Son YK, An WS. Effect of sodium bicarbonate administration on mortality in patients with lactic acidosis: a retrospective analysis. PLoS ONE. 2013;8(6):e65283.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Wilson RF, Spencer AR, Tyburski JG, Dolman H, Zimmerman LH. Bicarbonate therapy in severely acidotic trauma patients increases mortality. J Trauma Acute Care Surg. 2013;74(1):45–50 (discussion 50).

    Article  CAS  PubMed  Google Scholar 

  95. Jung B, Rimmele T, Le Goff C, Chanques G, Corne P, Jonquet O, et al. Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. A prospective, multiple-center study. Crit Care Lond Engl. 2011;15(5):R238.

    Article  Google Scholar 

  96. Mathieu D, Neviere R, Billard V, Fleyfel M, Wattel F. Effects of bicarbonate therapy on hemodynamics and tissue oxygenation in patients with lactic acidosis: a prospective, controlled clinical study. Crit Care Med. 1991;19(11):1352–6.

    Article  CAS  PubMed  Google Scholar 

  97. Cooper DJ, Walley KR, Wiggs BR, Russell JA. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study. Ann Intern Med. 1990;112(7):492–8.

    Article  CAS  PubMed  Google Scholar 

  98. Jaber S, Paugam C, Futier E, Lefrant J-Y, Lasocki S, Lescot T, et al. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet Lond Engl. 2018;392(10141):31–40.

    Article  CAS  Google Scholar 

  99. Weng Y-M, Wu S-H, Li W-C, Kuo C-W, Chen S-Y, Chen J-C. The effects of sodium bicarbonate during prolonged cardiopulmonary resuscitation. Am J Emerg Med. 2013;31(3):562–5.

    Article  PubMed  Google Scholar 

  100. Kawano T, Grunau B, Scheuermeyer FX, Gibo K, Dick W, Fordyce CB, et al. Prehospital sodium bicarbonate use could worsen long term survival with favorable neurological recovery among patients with out-of-hospital cardiac arrest. Resuscitation. 2017;119:63–9.

    Article  PubMed  Google Scholar 

  101. Kim J, Kim K, Park J, Jo YH, Lee JH, Hwang JE, et al. Sodium bicarbonate administration during ongoing resuscitation is associated with increased return of spontaneous circulation. Am J Emerg Med. 2016;34(2):225–9.

    Article  CAS  PubMed  Google Scholar 

  102. Wang C-H, Huang C-H, Chang W-T, Tsai M-S, Yu P-H, Wu Y-W, et al. The effects of calcium and sodium bicarbonate on severe hyperkalaemia during cardiopulmonary resuscitation: a retrospective cohort study of adult in-hospital cardiac arrest. Resuscitation. 2016;98:105–11.

    Article  PubMed  Google Scholar 

  103. Bar-Joseph G, Abramson NS, Kelsey SF, Mashiach T, Craig MT, Safar P, et al. Improved resuscitation outcome in emergency medical systems with increased usage of sodium bicarbonate during cardiopulmonary resuscitation. Acta Anaesthesiol Scand. 2005;49(1):6–15.

    Article  CAS  PubMed  Google Scholar 

  104. Vukmir RB, Katz L, Sodium Bicarbonate Study Group. Sodium bicarbonate improves outcome in prolonged prehospital cardiac arrest. Am J Emerg Med. 2006;24(2):156–61.

    Article  PubMed  Google Scholar 

  105. Monsieurs KG, Nolan JP, Bossaert LL, Greif R, Maconochie IK, Nikolaou NI, et al. European resuscitation council guidelines for resuscitation 2015: section 1. Executive summary. Resuscitation. 2015;95:1–80.

    Article  PubMed  Google Scholar 

  106. Joffre J, Bourcier S, Hariri G, Miailhe A-F, Bigé N, Dumas G, et al. Reversible microvascular hyporeactivity to acetylcholine during diabetic ketoacidosis. Crit Care Med. 2018;46(8):e772–8.

    Article  CAS  PubMed  Google Scholar 

  107. Duhon B, Attridge RL, Franco-Martinez AC, Maxwell PR, Hughes DW. Intravenous sodium bicarbonate therapy in severely acidotic diabetic ketoacidosis. Ann Pharmacother. 2013;47(7–8):970–5.

    Article  PubMed  CAS  Google Scholar 

  108. Viallon A, Zeni F, Lafond P, Venet C, Tardy B, Page Y, et al. Does bicarbonate therapy improve the management of severe diabetic ketoacidosis? Crit Care Med. 1999;27(12):2690–3.

    Article  CAS  PubMed  Google Scholar 

  109. Temple AR. Pathophysiology of aspirin overdosage toxicity, with implications for management. Pediatrics. 1978;62(5):873–6.

    CAS  PubMed  Google Scholar 

  110. Juurlink DN, Gosselin S, Kielstein JT, Ghannoum M, Lavergne V, Nolin TD, et al. Extracorporeal treatment for salicylate poisoning: systematic review and recommendations from the EXTRIP Workgroup. Ann Emerg Med. 2015;66(2):165–81.

    Article  PubMed  Google Scholar 

  111. Prescott LF, Balali-Mood M, Critchley JA, Johnstone AF, Proudfoot AT. Diuresis or urinary alkalinisation for salicylate poisoning? Br Med J Clin Res Ed. 1982;285(6352):1383–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Legrand M, Darmon M, Joannidis M, Payen D. Management of renal replacement therapy in ICU patients: an international survey. Intensive Care Med. 2013;39(1):101–8.

    Article  PubMed  Google Scholar 

  113. Wald R, McArthur E, Adhikari NKJ, Bagshaw SM, Burns KEA, Garg AX, et al. Changing incidence and outcomes following dialysis-requiring acute kidney injury among critically ill adults: a population-based cohort study. Am J Kidney Dis. 2015;65(6):870–7.

    Article  PubMed  Google Scholar 

  114. Zarbock A, Kellum JA, Schmidt C, Aken HV, Wempe C, Pavenstädt H, et al. Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA. 2016;315(20):2190–9.

    Article  CAS  PubMed  Google Scholar 

  115. Gaudry S, Hajage D, Schortgen F, Martin-Lefevre L, Pons B, Boulet E, et al. Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med. 2016;375(2):122–33.

    Article  PubMed  Google Scholar 

  116. Barbar SD, Clere-Jehl R, Bourredjem A, Hernu R, Montini F, Bruyère R, et al. Timing of renal-replacement therapy in patients with acute kidney injury and sepsis. N Engl J Med. 2018;379(15):1431–42.

    Article  CAS  PubMed  Google Scholar 

  117. Yeh H-C, Ting I-W, Tsai C-W, Wu J-Y, Kuo C-C. Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series. BMC Nephrol. 2017;18(1):229.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  118. Mariano F, Pozzato M, Inguaggiato P, Guarena C, Turello E, Manes M, et al. Metformin-associated lactic acidosis undergoing renal replacement therapy in intensive care units: a five-million population-based study in the North-West of Italy. Blood Purif. 2017;44(3):198–205.

    Article  CAS  PubMed  Google Scholar 

  119. Calello DP, Liu KD, Wiegand TJ, Roberts DM, Lavergne V, Gosselin S, et al. Extracorporeal treatment for metformin poisoning: systematic review and recommendations from the extracorporeal treatments in poisoning workgroup. Crit Care Med. 2015;43(8):1716–30.

    Article  PubMed  Google Scholar 

  120. Hovda KE, Hunderi OH, Tafjord A-B, Dunlop O, Rudberg N, Jacobsen D. Methanol outbreak in Norway 2002–2004: epidemiology, clinical features and prognostic signs. J Intern Med. 2005;258(2):181–90.

    Article  CAS  PubMed  Google Scholar 

  121. Kute VB, Godara SM, Shah PR, Gumber MR, Goplani KR, Vanikar AV, et al. Hemodialysis for methyl alcohol poisoning: a single-center experience. Saudi J Kidney Dis Transplant Off Publ Saudi Cent Organ Transplant Saudi Arab. 2012;23(1):37–43.

    Google Scholar 

  122. Liu JJ, Daya MR, Carrasquillo O, Kales SN. Prognostic factors in patients with methanol poisoning. J Toxicol Clin Toxicol. 1998;36(3):175–81.

    Article  CAS  PubMed  Google Scholar 

  123. Coulter CV, Farquhar SE, McSherry CM, Isbister GK, Duffull SB. Methanol and ethylene glycol acute poisonings—predictors of mortality. Clin Toxicol Phila Pa. 2011;49(10):900–6.

    Article  CAS  Google Scholar 

  124. Brent J, McMartin K, Phillips S, Aaron C, Kulig K, Methylpyrazole for Toxic Alcohols Study Group. Fomepizole for the treatment of methanol poisoning. N Engl J Med. 2001;344(6):424–9.

    Article  CAS  PubMed  Google Scholar 

  125. Mégarbane B, Borron SW, Baud FJ. Current recommendations for treatment of severe toxic alcohol poisonings. Intensive Care Med. 2005;31(2):189–95.

    Article  PubMed  Google Scholar 

  126. Roberts DM, Yates C, Megarbane B, Winchester JF, Maclaren R, Gosselin S, et al. Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: a systematic review and consensus statement. Crit Care Med. 2015;43(2):461–72.

    Article  CAS  PubMed  Google Scholar 

  127. McCabe DJ, Lu JJ. The association of hemodialysis and survival in intubated salicylate-poisoned patients. Am J Emerg Med. 2017;35(6):899–903.

    Article  PubMed  Google Scholar 

  128. Dempsey JA, Smith CA. Pathophysiology of human ventilatory control. Eur Respir J. 2014;44(2):495–512.

    Article  PubMed  PubMed Central  Google Scholar 

  129. Lumb A. Nunn’s applied respiratory physiology. 8th ed. New York: Elsevier; 2016.

    Google Scholar 

  130. Javaheri S, Corbett W, Wagner K, Adams JM. Quantitative cerebrospinal fluid acid–base balance in acute respiratory alkalosis. Am J Respir Crit Care Med. 1994;150(1):78–82.

    Article  CAS  PubMed  Google Scholar 

  131. Javaheri S, Herrera L, Kazemi H. Ventilatory drive in acute metabolic acidosis. J Appl Physiol. 1979;46(5):913–8.

    Article  CAS  PubMed  Google Scholar 

  132. Fulop M. Ventilatory response in patients with acute lactic acidosis. Crit Care Med. 1982;10(3):173–5.

    Article  CAS  PubMed  Google Scholar 

  133. Curley GF, Laffey JG. Acidosis in the critically ill—balancing risks and benefits to optimize outcome. Crit Care Lond Engl. 2014;18(2):129.

    Article  Google Scholar 

  134. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017;45:486–552.

    Google Scholar 

  135. Stengl M, Ledvinova L, Chvojka J, Benes J, Jarkovska D, Holas J, et al. Effects of clinically relevant acute hypercapnic and metabolic acidosis on the cardiovascular system: an experimental porcine study. Crit Care Lond Engl. 2013;17(6):R303.

    Article  Google Scholar 

  136. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Crit Care Med. 2017;45(3):486–552.

    Article  PubMed  Google Scholar 

  137. Brochard L, Slutsky A, Pesenti A. Mechanical ventilation to minimize progression of lung injury in acute respiratory failure. Am J Respir Crit Care Med. 2017;195(4):438–42.

    Article  PubMed  Google Scholar 

  138. Mascheroni D, Kolobow T, Fumagalli R, Moretti MP, Chen V, Buckhold D. Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. Intensive Care Med. 1988;15(1):8–14.

    Article  CAS  PubMed  Google Scholar 

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From: Diagnosis and management of metabolic acidosis: guidelines from a French expert panel

  Recommendation according to the GRADE methodology  
High level of evidence Strong recommendation
“… should be done…”
Grade 1+
Moderate level of evidence Optional recommendation
“… should probably be done…”
Grade 2+
Insufficient level of evidence Recommendation in the form of an expert opinion
“The experts suggest…”
Expert opinion
Moderate level of evidence Optional recommendation
“… should probably not be done…”
Grade 2−
High level of evidence Strong recommendation
“… should not be done…”
Grade 1−

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